Art. -Nr.: HY-115584

Lufenuron

1 Cited Publications

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Lufenuron is an orally active lipophilic benzoylurea insecticide and a chitin synthesis inhibitor that can used for flea and fish lice control. Lufenuron inhibits moulting of arthropods. Lufenuron induces reproductive toxicity, genotoxic effects and oxidative stresses in pregnant albino rats and their fetuses.

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Reinheit: 99.57%
CAS. Nr.: 103055-07-8
Formel: C₁₇H₈Cl₂F₈N₂O₃
Molecular Weight:511.15

Speicherung:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month

Lufenuron Chemical Structure

CAS. Nr.: 103055-07-8

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Biologische Aktivität
- Beschreibung
- In Vivo
Chemical Information
Publications (1)
Lösungsmittel & Löslichkeit
- In Vitro
- In Vivo
Reinheit & Dokumentation
Verweise
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

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In Vivo

Termites fed Lufenuron significantly increases the virulence of P. aeruginosa and Lufenuron blocks the formation of the exoskeleton in termite^[2].
Lufenuron (0.4 or 0.8 mg/kg of body weight, oral gavage, once daily at the same time over the seven days of the second gestation period (from 7 to 13th gestational day)) induces reproductive toxicity and genotoxic effects in pregnant albino rats and their fetuses^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Pregnant albino rats^[3]
Dosage:

0.4 or 0.8 mg/kg of body weight
Administration:

oral gavage, once daily at the same time over the seven days of the second gestation period (from 7 to 13th gestational day)
Result:

The fetuses extracted from Lufenuron-treated dams showed visible dead cases and multiple morphologic malformations; including hematoma, total foot loss in pregnant albino rats.

Chemical Information

CAS. Nr. 103055-07-8
Appearance Solid
Molecular Weight 511.15
Formel C₁₇H₈Cl₂F₈N₂O₃
Color Off-white to light yellow
SMILES

O=C(NC(NC1=CC(Cl)=C(OC(F)(F)C(F)C(F)(F)F)C=C1Cl)=O)C2=C(F)C=CC=C2F
Versand

Room temperature in continental US; may vary elsewhere.

Speicherung

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Publications (1)

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Journal Impact Factor

Insect Sci

Genetic and pharmacological inhibition of the Kir2A channel in diamondback moth exhibits ovicidal activity. [Abstract]

2026 May 11. PMID: 42116718

Lösungsmittel & Löslichkeit

In Vitro:

DMSO : 125 mg/mL (244.55 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

1.9564 mL

9.7819 mL

19.5637 mL

5 mM

0.3913 mL

1.9564 mL

3.9127 mL

10 mM

0.1956 mL

0.9782 mL

1.9564 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline

Solubility: ≥ 2.08 mg/mL (4.07 mM); Clear solution

This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

Protocol 2

Add each solvent one by one: 10% DMSO 90% Corn Oil

Solubility: ≥ 2.08 mg/mL (4.07 mM); Clear solution

This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg
Animal Weight (Per Animal) Animal Weight (Per Animal)
g
Dosing Volume (Per Animal) Dosing Volume (Per Animal)
μL
Number of Animals Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

%
DMSO +

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
%
+
+
%
Tween-80 + +
%
Saline +

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Working solution concentration: 0.22 mg/mL

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (273 KB)
SDS (597 KB)
- English - EN (597 KB)
- Français - FR (597 KB)
- Deutsch - DE (597 KB)
- Norwegian - NO (597 KB)
- Español - ES (597 KB)
- Swedish - SV (597 KB)
- Italian - IT (597 KB)
- Korean - KR (597 KB)
- Portuguese - PT (597 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. T C M Brock, et al. Toxicity of Sediment-Bound Lufenuron to Benthic Arthropods in Laboratory Bioassays. Aquat Toxicol. 2018 May;198:118-128. [Content Brief]

[2]. Cai Wang, et al. Lufenuron Suppresses the Resistance of Formosan Subterranean Termites (Isoptera: Rhinotermitidae) to Entomopathogenic Bacteria. J Econ Entomol. 2013 Aug;106(4):1812-8. [Content Brief]

[3]. Basal WT, et al. Lufenuron induces reproductive toxicity and genotoxic effects in pregnant albino rats and their fetuses. Sci Rep. 2020 Nov 11;10(1):19544. [Content Brief]

[4]. Ghazawy N. Ultrastructural observations on the gonads and neurosecretory cells of schistocerca gregaria after treatment with Lufenuron (CGA-184699)[J]. Journal of Orthoptera Research, 2012, 21(2): 141-148.

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	1.9564 mL	9.7819 mL	19.5637 mL	48.9093 mL
	5 mM	0.3913 mL	1.9564 mL	3.9127 mL	9.7819 mL
	10 mM	0.1956 mL	0.9782 mL	1.9564 mL	4.8909 mL
	15 mM	0.1304 mL	0.6521 mL	1.3042 mL	3.2606 mL
	20 mM	0.0978 mL	0.4891 mL	0.9782 mL	2.4455 mL
	25 mM	0.0783 mL	0.3913 mL	0.7825 mL	1.9564 mL
	30 mM	0.0652 mL	0.3261 mL	0.6521 mL	1.6303 mL
	40 mM	0.0489 mL	0.2445 mL	0.4891 mL	1.2227 mL
	50 mM	0.0391 mL	0.1956 mL	0.3913 mL	0.9782 mL
	60 mM	0.0326 mL	0.1630 mL	0.3261 mL	0.8152 mL
	80 mM	0.0245 mL	0.1223 mL	0.2445 mL	0.6114 mL
	100 mM	0.0196 mL	0.0978 mL	0.1956 mL	0.4891 mL

Keywords

Lufenuron

1 Cited Publications

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Lufenuron

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Publications Citing Use of MedChemExpress (MCE) Lufenuron

Alle Parasite Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Publications (1)

Lösungsmittel & Löslichkeit

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table

Lufenuron

Anti-Infection Compound Library

Anti-Aging Compound Library

Oxygen Sensing Compound Library

Orally Active Compound Library

FDA Approved & Pharmacopeial Drug Library

Antiparasitic Compound library

Anti-Parkinson's Disease Compound Library

Neurodegenerative Disease-related Compound Library

Human Metabolite Library

Mitochondrial Toxicity Compound Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Bioactive Compound Library

Pesticide Compound Library

High-Throughput Bioactive Compound Library

Mass Spectrometry Human Metabolite Library

Animal Drug Library

Environmental Pollutant Compound Library

Publications Citing Use of MedChemExpress (MCE) Lufenuron

Alle Parasite Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Publications (1)

Lösungsmittel & Löslichkeit

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table

Lufenuron Related Classifications

HY-115584 Related Classifications