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Art. -Nr.: HY-165615

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M&B 4935

M&B 4935 is an orally active Amoebicide. M&B 4935 reduces the levels of *Entamoeba histolytica* parasites in rodents. M&B 4935 can be used for the research of amoebiasis.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

CAS. Nr.: 3613-83-0
Formel: C₁₀H₁₁Cl₂NO₃
Molecular Weight:264.10

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

M&B 4935 Chemical Structure

CAS. Nr.: 3613-83-0

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- In Vitro
- In Vivo
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
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Biologische Aktivität

Beschreibung

M&B 4935 is an orally active Amoebicide. M&B 4935 reduces the levels of *Entamoeba histolytica* parasites in rodents. M&B 4935 can be used for the research of amoebiasis^[1].

Alle Parasite Isoform-spezifische Produkte anzeigen :

In Vitro

Parasitic Infection

M&B 4935 (24 h) exhibits amoebicidal activity against Entamoeba histolytica in vitro when tested as processed caecal extract, reducing the average Parasite Index to 0.3 and clearing 4/6 of test tubes of amoebae^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Parasitic Infection

M&B 4935 (1.0 g/kg; p.o.; 5 divided doses over 72 hours) exhibits in vivo amoebicidal activity in weanling rats with experimental Entamoeba histolytica caecal infection, reaching 74% of the activity of M&B 4321, and has a single-dose oral LD₅₀ of 1.5 g/kg in rats^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Albino rats (weanling)^[1]
Dosage:

1.0 g/kg (total divided dose); 1.0 g/kg (single dose); 1.5 g/kg (LD50)
Administration:

p.o.; 5 divided doses over 72 hours; single dose
Result:

Demonstrated an in vivo amoebicidal activity of 74 relative to M&B 4321 (set at 100).
Resulted in an average Parasite Index of 0.3 (maximum index = 4.0) and cleared amoebae in 4 out of 6 microtubes at a single oral dose of 1.0 g/kg.
Had a single-dose oral LD50 of 1.5 g/kg in rats.

Chemical Information

CAS. Nr. 3613-83-0
Molecular Weight 264.10
Formel C₁₀H₁₁Cl₂NO₃
SMILES

O=C(N(C1=CC=C(O)C=C1)CCO)C(Cl)Cl
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Handling Instructions (2659 KB)

Verweise

[1]. KIDD DA, et al. Amoebicidal activity of dichloro-N-2-hydroxy-ethyl-N-p-methylsulphonylbenzylacetamide and some related compounds. Br J Pharmacol Chemother. 1962 Feb;18(1):128-37. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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