Maprotiline
Based on 4 publication(s) in Google Scholar
Maprotiline is a highly selective noradrenergic reuptake inhibitor that has strong antidepressant, antitumor and neuropathic pain-relieving effects. Maprotiline induces cancer cell apoptosis by targeting the ERK signaling pathway and CRABP1.
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- CAS. Nr.: 10262-69-8
- Formel: C20H23N
- Molecular Weight:277.40
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Speicherung:
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Biologische Aktivität
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Publications Citing Use of MedChemExpress (MCE) Maprotiline
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Biologische Aktivität
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| DG-75 | EC50 |
37.5 μM
Compound: 1
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Antiproliferative activity against human DG75 cells after 72 hrs by Alamar blue assay
Antiproliferative activity against human DG75 cells after 72 hrs by Alamar blue assay
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[PMID: 24333581] |
| Ventricular myocyte | IC50 |
31 μM
Compound: Maprotiline
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Inhibition of L-type calcium channel measured using whole-cell patch clamp in rat ventricular myocytes
Inhibition of L-type calcium channel measured using whole-cell patch clamp in rat ventricular myocytes
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[PMID: 22761000] |
Maprotiline (0-20 μM, 0-72 h) inhibits the growth of Huh7 and HepG2 cells and induces cell apoptosis[1].
Maprotiline (0-20 μM, 0-72 h) inhibits the metastasis of liver cancer cells[1].
Maprotiline (0-20 μM, 72 h) affects the ERK pathway and inhibits the phosphorylation of SREBP2 in HepG2 and Huh7 cells[1].
Maprotiline targets CRABP1 and regulates cholesterol biosynthesis in HCC cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:The human HCC cell lines Huh7 and HepG2
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Concentration:0, 10, 20 μM
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Incubation Time:24 hours
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Result:Restrained HCC cells migration with inhibition of epithelial-mesenchymal transition (EMT).
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Cell Line:The human HCC cell lines Huh7 and HepG2
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Concentration:0, 10, 20 μM
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Incubation Time:0, 24, 48, 72, 96, 120 hours
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Result:Triggered cell apoptosis and inhibited the cell viability of Huh7 and HepG2 cells in a dose- and time-dependent manner.
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Cell Line:The human HCC cell lines Huh7 and HepG2
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Concentration:0, 10, 20 μM
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Incubation Time:72 hours
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Result:Inhibited cholesterol biosynthesis in HCC Cells.
Maprotiline (3-30 mg/kg, intravenous injection, single dose) combined with the synthetic cannabinoid WIN 55,212-2 effectively reduces neuropathic pain in mice[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Nude mice (BALB/C nu/nu, 4–6 weeks old, female)[1]
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Dosage:20, 40 mg/kg
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Administration:Intraperitoneal injection (i.p.); twice a week; 3 weeks
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Result:Decreased the cholesterol levels in serum and tumors and suppressed the growth of Huh7-derived tumor xenografts without obvious toxic effect.
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Animal Model:Male Balb-c mice (25–30 g)[2]
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Dosage:3, 10, 30 mg/kg; single dose
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Administration:Intravenous injection (i.v.)
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Result:Attenuated pain-related behaviours in neuropathic mice.
Chemical Information
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CAS. Nr. 10262-69-8
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Molecular Weight 277.40
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Formel C20H23N
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SMILES
CNCCCC12C3=C(C=CC=C3)C(CC2)C4=CC=CC=C14
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (4)
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Journal Impact Factor
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Most Recent
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Autophagy
2025 May;21(5):934-956. PMID: 39663580 -
Adv Sci (Weinh)
Network Medicine-Based Strategy Identifies Maprotiline as a Repurposable Drug by Inhibiting PD-L1 Expression via Targeting SPOP in Cancer. [Abstract]2025 Jan;12(1):e2410285. PMID: 39499771 -
Cell Rep Methods
RECOVER identifies synergistic drug combinations in vitro through sequential model optimization. [Abstract]2023 Oct 23;3(10):100599. PMID: 37797618 -
PLoS Negl Trop Dis
Identification of anti-flaviviral drugs with mosquitocidal and anti-Zika virus activity in Aedes aegypti. [Abstract]2019 Aug 20;13(8):e0007681. PMID: 31430351
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