MDL 73811
MDL 73811 is a potent AdoMetDC inhibitor and anti-trypanosomal compound. MDL 73811 has curative efficacy in a hemolymphatic model of HAT.
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- CAS. Nr.: 123642-27-3
- Formel: C15H23N7O3
- Molecular Weight:349.39
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
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Biologische Aktivität
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Trypanosoma |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A549 | IC50 |
3 μM
Compound: AbeAdo
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In vitro Antineoplastic Activity against Human non small cell lung carcinoma A549 Cell lines
In vitro Antineoplastic Activity against Human non small cell lung carcinoma A549 Cell lines
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[PMID: 12408722] |
| HT-29 | IC50 |
>100 μM
Compound: AbeAdo
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In vitro Neoplastic Anti Activity in Human Colon adenocarcinoma HT-29 Cell lines
In vitro Neoplastic Anti Activity in Human Colon adenocarcinoma HT-29 Cell lines
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[PMID: 12408722] |
| MCF7 | IC50 |
>100 μM
Compound: AbeAdo
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In vitro Neoplastic Anti Activity against Human Breast adenocarcinoma MCF-7 Cell lines
In vitro Neoplastic Anti Activity against Human Breast adenocarcinoma MCF-7 Cell lines
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[PMID: 12408722] |
| MCF7 | IC50 |
200 μM
Compound: AbeAdo
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In vitro Antineoplastic Activity against Adriamycin resistant Human Breast adenocarcinoma MCF7-Adr Cell lines
In vitro Antineoplastic Activity against Adriamycin resistant Human Breast adenocarcinoma MCF7-Adr Cell lines
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[PMID: 12408722] |
Chemical Information
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CAS. Nr. 123642-27-3
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Molecular Weight 349.39
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Formel C15H23N7O3
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SMILES
O[C@@H]1[C@H](O)[C@@H](CN(C)C/C=C\CN)O[C@H]1N2C=NC3=C(N)N=CN=C32
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
[1]. Brockway AJ, et al. Synthesis and evaluation of analogs of 5'-(((Z)-4-amino-2-butenyl)methylamino)-5'-deoxyadenosine (MDL 73811, or AbeAdo) - An inhibitor of S-adenosylmethionine decarboxylase with antitrypanosomal activity. Bioorg Med Chem. 2017 Oct 15;25(20):5433-5440. [Content Brief]
[2]. Brockway AJ , et al. Improved Synthesis of MDL 73811 - a Potent AdoMetDC Inhibitor and Anti-Trypanosomal Compound. Synthesis (Stuttg). 2016 Jul;48(13):2065-2068. [Content Brief]
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
MDL 73811 Related Classifications
HY-112252 Related Classifications
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