Mofarotene
Mofarotene (Ro 40-8757), an arotinoid, is anticancer compound. Mofarotene induces apoptosis, associated with mitochondrial membrane depolarization, activation of caspase-3 and -9, and enhanced production of reactive oxygen species. Mofarotene inhibits hematopoiesis in vitro by inhibiting maturation from primitive progenitor cells.
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- CAS. Nr.: 125533-88-2
- Formel: C29H39NO2
- Molecular Weight:433.63
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
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Biologische Aktivität
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Caspase 3 |
Caspase-9 |
Chemical Information
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CAS. Nr. 125533-88-2
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Molecular Weight 433.63
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Formel C29H39NO2
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SMILES
CC1(C2=CC(/C(C)=C/C3=CC=C(C=C3)OCCN4CCOCC4)=CC=C2C(C)(CC1)C)C
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Synonyms
Ro 40-8757
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
[1]. Valles B, et al. Metabolism of mofarotene in hepatocytes and liver microsomes from different species. Comparison with in vivo data and evaluation of the cytochrome P450 isoenzymes involved in human biotransformation. Drug Metab Dispos. 1995 Oct;23(10):1051-7. [Content Brief]
[2]. Eliason JF, et al. Mofarotene (Ro 40-8757) inhibits hematopoiesis in vitro by preventing maturation from primitive progenitor cells. Blood. 1995 Dec 15;86(12):4516-26. [Content Brief]
[3]. Cariati R, et al. Inhibition of oxidative phosphorylation underlies the antiproliferative and proapoptotic effects of mofarotene (Ro 40-8757) in Burkitt's lymphoma cells. Oncogene. 2003 Feb 13;22(6):906-18. [Content Brief]
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Mofarotene Related Classifications
HY-127149 Related Classifications
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