Moronic acid
Based on 1 publication(s) in Google Scholar
Moronic Acid is a triterpenoid compound, which is an orally available anti-HIV agent with anti-inflammatory activity. Moronic Acid can inhibit viral replication, with an EC50 value of <1 μg/mL. Moronic Acid can be isolated from Brazilian propolis.
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- Reinheit: 98.6%
- CAS. Nr.: 6713-27-5
- Formel: C30H46O3
- Molecular Weight:454.68
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Speicherung:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biologische Aktivität
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Chemical Information
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Lösungsmittel & Löslichkeit
- Reinheit & Dokumentation
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Moronic acid
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Biologische Aktivität
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NLRP3 |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A2780 | IC50 |
13.1 μg/mL
Compound: 6
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Cytotoxicity against human A2780 cells
Cytotoxicity against human A2780 cells
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[PMID: 15217279] |
| A549 | IC50 |
47 μM
Compound: 4a
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Cytotoxicity against human A549 cells assessed as reduction in cell viability incubated for 72 hrs by MTS assay
Cytotoxicity against human A549 cells assessed as reduction in cell viability incubated for 72 hrs by MTS assay
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[PMID: 36174412] |
| BJ | IC50 |
>50 μM
Compound: 4a
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Cytotoxicity against human BJ cells assessed as reduction in cell viability incubated for 72 hrs by MTS assay
Cytotoxicity against human BJ cells assessed as reduction in cell viability incubated for 72 hrs by MTS assay
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[PMID: 36174412] |
| CCRF-CEM | IC50 |
17 μM
Compound: 4a
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Cytotoxicity against human CCRF-CEM cells assessed as reduction in cell viability incubated for 72 hrs by MTS assay
Cytotoxicity against human CCRF-CEM cells assessed as reduction in cell viability incubated for 72 hrs by MTS assay
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[PMID: 36174412] |
| CEM-DNR | IC50 |
17 μM
Compound: 4a
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Cytotoxicity against human CEM-DNR cells assessed as reduction in cell viability incubated for 72 hrs by MTS assay
Cytotoxicity against human CEM-DNR cells assessed as reduction in cell viability incubated for 72 hrs by MTS assay
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[PMID: 36174412] |
| H9 | EC50 |
<0.1 μg/mL
Compound: 2
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Antiviral activity against HIV1 3B infected in human H9 cells assessed as inhibition of viral p24 antigen levels after 4 days by ELISA
Antiviral activity against HIV1 3B infected in human H9 cells assessed as inhibition of viral p24 antigen levels after 4 days by ELISA
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[PMID: 11678650] |
| H9 | EC50 |
<0.22 μM
Compound: 129
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Antiviral activity against HIV1 3B infected in H9 cells assessed as inhibition of viral replication by p24 antigen ELISA
Antiviral activity against HIV1 3B infected in H9 cells assessed as inhibition of viral replication by p24 antigen ELISA
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[PMID: 20187635] |
| H9 | IC50 |
18.6 μg/mL
Compound: 2
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Cytotoxicity against human H9 cells
Cytotoxicity against human H9 cells
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[PMID: 11678650] |
| HCT-116 | IC50 |
45 μM
Compound: 4a
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Cytotoxicity against human HCT-116 cells assessed as reduction in cell viability incubated for 72 hrs by MTS assay
Cytotoxicity against human HCT-116 cells assessed as reduction in cell viability incubated for 72 hrs by MTS assay
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[PMID: 36174412] |
| K562 | IC50 |
>50 μM
Compound: 4a
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Cytotoxicity against human K562 cells assessed as reduction in cell viability incubated for 72 hrs by MTS assay
Cytotoxicity against human K562 cells assessed as reduction in cell viability incubated for 72 hrs by MTS assay
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[PMID: 36174412] |
| MRC5 | IC50 |
>50 μM
Compound: 4a
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Cytotoxicity against human MRC5 cells assessed as reduction in cell viability incubated for 72 hrs by MTS assay
Cytotoxicity against human MRC5 cells assessed as reduction in cell viability incubated for 72 hrs by MTS assay
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[PMID: 36174412] |
| U2OS | IC50 |
>50 μM
Compound: 4a
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Cytotoxicity against human U2OS cells assessed as reduction in cell viability incubated for 72 hrs by MTS assay
Cytotoxicity against human U2OS cells assessed as reduction in cell viability incubated for 72 hrs by MTS assay
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[PMID: 36174412] |
Moronic Acid is cytotoxic to H9 lymphocytes, with an IC50 value of 18.6 μg/mL[1].
Moronic Acid (10-20 μM) inhibits the polarization of intestinal macrophages to M1, reducing ROS levels as well as the expression of p-P50 and NLRP3 proteins[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Intestinal macrophages
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Concentration:10, 20 μM
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Incubation Time:
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Result:Reduced expression of p-P50 and NLRP3 proteins.
Moronic Acid extends the survival time of HSV-1 infected mice and slows the progression of skin lesions[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Mice induced by DSS[2]
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Dosage:5, 10 mg/kg; daily; 20 days
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Administration:i.g.
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Result:Inhibited intestinal macrophage M1 polarization, inhibited the expression of inflammatory factors, and reduced ROS-NF-κB-NLRP3 signaling levels.
Chemical Information
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CAS. Nr. 6713-27-5
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Appearance Solid
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Molecular Weight 454.68
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Formel C30H46O3
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Color White to off-white
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SMILES
C[C@]12[C@]3([C@@](CC[C@]1([H])[C@@]4([C@@](C(C)(C(CC4)=O)C)([H])CC2)C)([H])C5=CC(C)(C)CC[C@@]5(CC3)C(O)=O)C
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Synonyms
(+)-Moronic acid
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Structure Classification
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Initial Source
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Publications (1)
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Journal Impact Factor
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Most Recent
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Phytomedicine
Moronic acid alleviates non-alcoholic fatty liver disease and fibrosis through PPARs-mediated lipidomic reprogramming. [Abstract]2025 Dec:149:157519. PMID: 41242309
Lösungsmittel & Löslichkeit
DMSO : 18.6 mg/mL (40.91 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Reinheit & Dokumentation
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Data Sheet (278 KB)
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SDS (396 KB)
- English - EN (396 KB)
- Français - FR (396 KB)
- Deutsch - DE (396 KB)
- Norwegian - NO (396 KB)
- Español - ES (396 KB)
- Swedish - SV (396 KB)
- Italian - IT (396 KB)
- Korean - KR (396 KB)
- Portuguese - PT (396 KB)
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Handling Instructions (2659 KB)
Verweise
[1]. Ito J, et al. Anti-AIDS agents. 48.(1) Anti-HIV activity of moronic acid derivatives and the new melliferone-related triterpenoid isolated from Brazilian propolis. J Nat Prod. 2001 Oct;64(10):1278-81. [Content Brief]
[2]. Shuiliang Ruan, et al. Moronic acid improves intestinal inflammation in mice with chronic colitis by inhibiting intestinal macrophage polarization. J Biochem Mol Toxicol. 2022 Nov;36(11):e23188. [Content Brief]
[3]. M Kurokawa, et al. Anti-herpes simplex virus activity of moronic acid purified from Rhus javanica in vitro and in vivo. J Pharmacol Exp Ther. 1999 Apr;289(1):72-8. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.1993 mL | 10.9967 mL | 21.9935 mL | 54.9837 mL |
| 5 mM | 0.4399 mL | 2.1993 mL | 4.3987 mL | 10.9967 mL | |
| 10 mM | 0.2199 mL | 1.0997 mL | 2.1993 mL | 5.4984 mL | |
| 15 mM | 0.1466 mL | 0.7331 mL | 1.4662 mL | 3.6656 mL | |
| 20 mM | 0.1100 mL | 0.5498 mL | 1.0997 mL | 2.7492 mL | |
| 25 mM | 0.0880 mL | 0.4399 mL | 0.8797 mL | 2.1993 mL | |
| 30 mM | 0.0733 mL | 0.3666 mL | 0.7331 mL | 1.8328 mL | |
| 40 mM | 0.0550 mL | 0.2749 mL | 0.5498 mL | 1.3746 mL |
Moronic acid Related Classifications
HY-N3242 Related Classifications
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