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Art. -Nr.: HY-148771

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MTX-23

Name: MTX-23
Brand: MedChemExpress
SKU: HY-148771
Price: 130.00 USD
Availability: InStock
Rating: 5 (1 reviews)

(Synonyms: PROTAC AR-V7 degrader-2)

1 Cited Publications

Kundenbewertung

Based on 1 publication(s) in Google Scholar

MTX-23 is a PROTAC degrader targeting androgen receptor splice variant 7 (AR-V7) and full-length androgen receptor (AR-FL), with DC₅₀ values of 0.37 μM and 2 μM, respectively. MTX-23 binds to the DNA-binding domains of AR-V7 and AR-FL, recruits the VHL E3 ubiquitin ligase (E3 ubiquitin ligase) and induces their degradation. MTX-23 reduces the proliferation of prostate cancer cells, promotes their apoptosis (apoptosis), and also inhibits tumor growth in mouse models. MTX-23 can be used for the research of prostate cancer.
(Pink: AR-V7 ligand (HY-175939); Blue: VHL ligand (HY-112078); Black: linker).

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

Reinheit : 99.79%
CAS. Nr.: 2488296-74-6
Formel: C₄₃H₅₃F₂N₇O₇S₂
Molecular Weight:882.05

Speicherung:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month

MTX-23 Chemical Structure

CAS. Nr.: 2488296-74-6

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
Chemical Information
Publications (1)
Lösungsmittel & Löslichkeit
- In Vitro
Reinheit & Dokumentation
Verweise
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

MTX-23 is a PROTAC degrader targeting androgen receptor splice variant 7 (AR-V7) and full-length androgen receptor (AR-FL), with DC₅₀ values of 0.37 μM and 2 μM, respectively. MTX-23 binds to the DNA-binding domains of AR-V7 and AR-FL, recruits the VHL E3 ubiquitin ligase (E3 ubiquitin ligase) and induces their degradation. MTX-23 reduces the proliferation of prostate cancer cells, promotes their apoptosis (apoptosis), and also inhibits tumor growth in mouse models. MTX-23 can be used for the research of prostate cancer^[1]. (Pink: AR-V7 ligand (HY-175939); Blue: VHL ligand (HY-112078); Black: linker).

IC₅₀ & Target

^[1]

AR-V7

0.37 μM (DC₅₀)

AR-FL

2 μM (DC₅₀)

Alle PROTACs Isoform-spezifische Produkte anzeigen :

In Vitro

OthersAnti-cancerApoptosis

Others

MTX-23 degrades AR-V7 with a DC₅₀ of 0.37 μmol/L and AR-FL with a DC₅₀ of 2 μmol/L as measured by immunoblot analysis^[1].

Anti-cancer

Apoptosis

MTX-23 inhibits proliferation and increases apoptosis in androgen-responsive prostate cancer cells, with this antiproliferative effect dependent on the presence of AR-V7 and AR-FL^[1].

Anti-cancer

MTX-23 inhibits proliferation in 12 human prostate cancer cell lines resistant to second-line antiandrogen therapies^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Related Protocols :

Chemical Information

CAS. Nr. 2488296-74-6
Appearance Solid
Molecular Weight 882.05
Formel C₄₃H₅₃F₂N₇O₇S₂
Color Off-white to light yellow
SMILES

O=C(N1[C@@H](C[C@H](C1)O)C(N[C@H](C2=CC=C(C3=C(N=CS3)C)C=C2)C)=O)[C@H](C(C)(C)C)NC(CCCCNC(COC4=C(C5=CSC(N6CCOCC6)=N5)C=CC(F)=C4F)=O)=O
Synonyms

PROTAC AR-V7 degrader-2
Versand

Room temperature in continental US; may vary elsewhere.

Speicherung

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Publications (1)

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Journal Impact Factor

Nature

Androgen activity in the male embryonic hindbrain drives lethal PFA ependymoma. [Abstract]

2026 Apr;652(8110):763-773. PMID: 41882358

Lösungsmittel & Löslichkeit

In Vitro:

DMSO : 100 mg/mL (113.37 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

1.1337 mL

5.6686 mL

11.3372 mL

5 mM

0.2267 mL

1.1337 mL

2.2674 mL

10 mM

0.1134 mL

0.5669 mL

1.1337 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (276 KB)
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Lee GT, et al. Effects of MTX-23, a Novel PROTAC of Androgen Receptor Splice Variant-7 and Androgen Receptor, on CRPC Resistant to Second-Line Antiandrogen Therapy. Mol Cancer Ther. 2021 Mar;20(3):490-499. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	1.1337 mL	5.6686 mL	11.3372 mL	28.3431 mL
	5 mM	0.2267 mL	1.1337 mL	2.2674 mL	5.6686 mL
	10 mM	0.1134 mL	0.5669 mL	1.1337 mL	2.8343 mL
	15 mM	0.0756 mL	0.3779 mL	0.7558 mL	1.8895 mL
	20 mM	0.0567 mL	0.2834 mL	0.5669 mL	1.4172 mL
	25 mM	0.0453 mL	0.2267 mL	0.4535 mL	1.1337 mL
	30 mM	0.0378 mL	0.1890 mL	0.3779 mL	0.9448 mL
	40 mM	0.0283 mL	0.1417 mL	0.2834 mL	0.7086 mL
	50 mM	0.0227 mL	0.1134 mL	0.2267 mL	0.5669 mL
	60 mM	0.0189 mL	0.0945 mL	0.1890 mL	0.4724 mL
	80 mM	0.0142 mL	0.0709 mL	0.1417 mL	0.3543 mL
	100 mM	0.0113 mL	0.0567 mL	0.1134 mL	0.2834 mL

Bioz

MTX-23

1 Cited Publications

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Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
Chemical Information
Publications (1)
Lösungsmittel & Löslichkeit
- In Vitro
Reinheit & Dokumentation
Verweise

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MTX-23

Publications Citing Use of MedChemExpress (MCE) MTX-23

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