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Art. -Nr.: HY-148771

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MTX-23

(Synonyms: PROTAC AR-V7 degrader-2)

1 Cited Publications

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Based on 1 publication(s) in Google Scholar

MTX-23 is an AR-based PROTAC. MTX-23 inhibits CaP cellular proliferation by degrading AR-V7 and AR-FL. MTX-23 induces apoptosis.
(Pink: AR-V7 Target protein ligand; Blue: VHL ligand (HY-112078); Black: linker).

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Reinheit: 99.79%
CAS. Nr.: 2488296-74-6
Formel: C₄₃H₅₃F₂N₇O₇S₂
Molecular Weight:882.05

Speicherung:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month

MTX-23 Chemical Structure

CAS. Nr.: 2488296-74-6

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- In Vitro
- In Vivo
Chemical Information
Publications (1)
Lösungsmittel & Löslichkeit
- In Vitro
Reinheit & Dokumentation
Verweise
Help & FAQs
Bioz

Biologische Aktivität

Beschreibung

MTX-23 is an AR-based PROTAC. MTX-23 inhibits CaP cellular proliferation by degrading AR-V7 and AR-FL. MTX-23 induces apoptosis^[1]. (Pink: AR-V7 Target protein ligand; Blue: VHL ligand (HY-112078); Black: linker).

Alle PROTACs Isoform-spezifische Produkte anzeigen :

In Vitro

MTX-23 (compound 16; 0-20 μM; 4 d; 22Rvl cells) inhibits cell growth in dose-dependent manner^[1].
MTX-23 (10 μM; 4 d; 22Rvl cells) reduces AR-V7 protein levels^[1].
MTX-23 (1 μM; 0-48 h; 22Rvl cells) induces apoptosis and increases annexin-V staining^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:

22Rvl cells
Concentration:

0-20 μM
Incubation Time:

4 days
Result:

Reduced the cell count by less than 50 percent.

Apoptosis Analysis^[1]

Cell Line:

22Rvl cells
Concentration:

1 μM
Incubation Time:

0-48 h
Result:

Induced cell apoptosis in 22Rvl cells.

Western Blot Analysis^[1]

Cell Line:

22Rvl cells
Concentration:

10 μM
Incubation Time:

4 days
Result:

Reduced AR-V7 protein levels.

In Vivo

MTX-23 (compound 16; 2.5 mg/mL; intratumor injection) inhibits tumor growth in nu/nu mice with 22Rvl-Enz^R tumor xenografts^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

nu/nu mice with 22Rvl-Enz^R tumor xenografts^[1]
Dosage:

2.5 mg/mL
Administration:

intratumor injection
Result:

Inhibited tumor growth in nu/nu mice with 22Rvl-Enz^R tumor xenografts.

Chemical Information

CAS. Nr. 2488296-74-6
Appearance Solid
Molecular Weight 882.05
Formel C₄₃H₅₃F₂N₇O₇S₂
Color Off-white to light yellow
SMILES

O=C(N1[C@@H](C[C@H](C1)O)C(N[C@H](C2=CC=C(C3=C(N=CS3)C)C=C2)C)=O)[C@H](C(C)(C)C)NC(CCCCNC(COC4=C(C5=CSC(N6CCOCC6)=N5)C=CC(F)=C4F)=O)=O
Synonyms

PROTAC AR-V7 degrader-2
Versand

Room temperature in continental US; may vary elsewhere.

Speicherung

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Publications (1)

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Journal Impact Factor

Nature

Androgen activity in the male embryonic hindbrain drives lethal PFA ependymoma. [Abstract]

2026 Apr;652(8110):763-773. PMID: 41882358

Lösungsmittel & Löslichkeit

In Vitro:

DMSO : 100 mg/mL (113.37 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

1.1337 mL

5.6686 mL

11.3372 mL

5 mM

0.2267 mL

1.1337 mL

2.2674 mL

10 mM

0.1134 mL

0.5669 mL

1.1337 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (276 KB)
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Portuguese - PT (393 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Jenny D, et, al. Bi-functional compounds and methods for targeted ubiquitination of androgen receptor. WO2021236695.

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	1.1337 mL	5.6686 mL	11.3372 mL	28.3431 mL
	5 mM	0.2267 mL	1.1337 mL	2.2674 mL	5.6686 mL
	10 mM	0.1134 mL	0.5669 mL	1.1337 mL	2.8343 mL
	15 mM	0.0756 mL	0.3779 mL	0.7558 mL	1.8895 mL
	20 mM	0.0567 mL	0.2834 mL	0.5669 mL	1.4172 mL
	25 mM	0.0453 mL	0.2267 mL	0.4535 mL	1.1337 mL
	30 mM	0.0378 mL	0.1890 mL	0.3779 mL	0.9448 mL
	40 mM	0.0283 mL	0.1417 mL	0.2834 mL	0.7086 mL
	50 mM	0.0227 mL	0.1134 mL	0.2267 mL	0.5669 mL
	60 mM	0.0189 mL	0.0945 mL	0.1890 mL	0.4724 mL
	80 mM	0.0142 mL	0.0709 mL	0.1417 mL	0.3543 mL
	100 mM	0.0113 mL	0.0567 mL	0.1134 mL	0.2834 mL

Keywords

MTX-23

1 Cited Publications

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Biologische Aktivität
- Beschreibung
- In Vitro
- In Vivo
Chemical Information
Publications (1)
Lösungsmittel & Löslichkeit
- In Vitro
Reinheit & Dokumentation
Verweise

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MTX-23

Apoptosis Compound Library

Anti-Cancer Compound Library

Transcription Factor-Targeted Library

Anti-Prostate Cancer Compound Library

Nuclear Receptor Compound Library

PROTAC Library

Cell Death Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Bioactive Compound Library

Non-Alcoholic Fatty Liver Disease (NAFLD) Compound Library

High-Throughput Bioactive Compound Library

Publications Citing Use of MedChemExpress (MCE) MTX-23

Alle PROTACs Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Publications (1)

Lösungsmittel & Löslichkeit

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table

MTX-23

Apoptosis Compound Library

Anti-Cancer Compound Library

Transcription Factor-Targeted Library

Anti-Prostate Cancer Compound Library

Nuclear Receptor Compound Library

PROTAC Library

Cell Death Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Bioactive Compound Library

Non-Alcoholic Fatty Liver Disease (NAFLD) Compound Library

High-Throughput Bioactive Compound Library

Publications Citing Use of MedChemExpress (MCE) MTX-23

Alle PROTACs Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Publications (1)

Lösungsmittel & Löslichkeit

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table

MTX-23 Related Classifications

Art. -Nr.: HY-148771