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Art. -Nr.: HY-N21816

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OM-4842

OM-4842 is an ansamycin antibiotic and platelet aggregation inhibitor derived from Streptomyces. OM-4842 inhibits platelet aggregation induced by Adenosine 5'-diphosphate (ADP) (HY-W010918), Arachidonic acid (HY-109590), and C16-PAF (PAF) (HY-108635), and exerts growth-inhibitory activity against Doxorubicin (HY-15142A)-resistant P388 mouse leukemia cells. OM-4842 is used in research on platelet aggregation-related disorders and drug-resistant leukemia.

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CAS. Nr.: 115626-67-0
Formel: C₃₇H₄₆O₁₄
Molecular Weight:714.75

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

OM-4842 Chemical Structure

CAS. Nr.: 115626-67-0

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- Cellular Effect
- In Vitro
- In Vivo
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

Alle Antibiotic Isoform-spezifische Produkte anzeigen :

Cellular Effect

Cell Line	Type	Value	Description	References
P388/ADR	MIC	1.5 μg/mL	Cytotoxicity against doxorubicin-resistant P388 mouse leukemia cells, quantified as inhibition of cell growth. Cytotoxicity against doxorubicin-resistant P388 mouse leukemia cells, quantified as inhibition of cell growth.	39852527
Platelet	MIC	5.0 μg/mL	Inhibition of ADP-induced platelet aggregation in cultured platelets. Inhibition of ADP-induced platelet aggregation in cultured platelets.	39852527
Platelet	MIC	12.5 μg/mL	Inhibition of arachidonic acid-induced platelet aggregation in cultured platelets. Inhibition of arachidonic acid-induced platelet aggregation in cultured platelets.	39852527
Platelet	MIC	25 μg/mL	Inhibition of PAF- or collagen-induced platelet aggregation in cultured platelets. Inhibition of PAF- or collagen-induced platelet aggregation in cultured platelets.	39852527

In Vitro

Anti-cancerOthers

Anti-cancer

OM-4842 (1.5 μg/mL; 72 h) inhibits the growth of Doxorubicin (HY-15142A)-resistant P388 murine leukemia cells in vitro^[1].
OM-4842 (compound 143) (1.5 µg/mL) inhibits the growth of Doxorubicin-resistant P388 mouse leukemia cells^[3].

Others

OM-4842 (compound 3) is an intermediate in the urdamycin biosynthetic pathway in Streptomyces fradiae (strain Tu 2717). It is produced from aquayamycin and subsequently converted to urdamycin A^[2].
OM-4842 (5.0-25 µg/mL) inhibits platelet aggregation induced by ADP, arachidonic acid, PAF, and collagen, with MIC₅₀ values of 5.0, 12.5, and 25 µg/mL, respectively^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay^[1]

Cell Line:

doxorubicin-resistant P388 mouse leukemia cells
Concentration:

1.5 μg/mL
Incubation Time:

72 h
Result:

Inhibited the growth of Doxorubicin-resistant P388 mouse leukemia cells.

In Vivo

OM‑4842 (200 μg/kg; i.v.) exhibits acute toxicity in ddY mice with an intravenous LD₅₀ value of approximately 200 μg/kg^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

ddY mice^[1]
Dosage:

200 μg/kg
Administration:

i.v.
Result:

Reached an acute toxicity LD₅₀ of approximately 200 μg/kg.

Chemical Information

CAS. Nr. 115626-67-0
Molecular Weight 714.75
Formel C₃₇H₄₆O₁₄
SMILES

O=C(C1=C(O)C([C@H]2C[C@H]([C@@H]([C@H](O2)C)O)O[C@@H]3O[C@H]([C@H](CC3)O)C)=CC=C1C4=O)C(C=C[C@@]5(C[C@@](O)(CC6=O)C)O)=C4[C@]56O[C@@H]7O[C@H]([C@H](CC7)O)C
Structure Classification
- Quinones
- Anthraquinones
Initial Source
- Microorganism
Streptomyces
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Handling Instructions (2659 KB)

Verweise

[1]. Omura S, et al. OM-4842, a new platelet aggregation inhibitor from Streptomyces. J Antibiot (Tokyo). 1988 Jun;41(6):812-3.

[2]. Gyorgyi Udvarnoki, et al. Biosynthetic origin of the oxygen atoms of aquayamycin: aspects for the biosynthesis of the urdamycin family and for aquayamycin-containing angucycline antibiotics in general. Journal of Organic Chemistry 1 February 1992; 57 (4): 1274–1276.

[3]. Liu HS, et al. Bioactive Angucyclines/Angucyclinones Discovered from 1965 to 2023. Marine drugs. 2025 Jan 05;23(1):25.

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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