Oxantel
Oxantel (CP-14445) is an anthelmintic agent that potently against Trichuris muris. Oxantel inhibits fumarate reductase (Frd) activity in some pathogenic bacteria and inhibits P. gingivalis homotypic biofilm formation (IC50 of 2.2 μM).
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- CAS. Nr.: 36531-26-7
- Formel: C13H16N2O
- Molecular Weight:216.28
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
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Biologische Aktivität
Oxantel ( 0.015-600 μg/mL; 24-72 hours) reduces the viability of T. muris[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:T. muris
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Concentration:0.015 µg/mL, 0.3 µg/mL, 0.6 µg/mL, 4.66 µg/mL, 9.375 µg/mL, 150 µg/mL, 600 µg/mL
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Incubation Time:24 hours, 48 hours, 72 hours
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Result:Resulted in strongly reduced viabilities; resulted in strongly reduced viabilities within 24 hours but did not kill the worms.
Oxantel (10 mg/kg; i.p.) exhibits a worm burden reduction (WBR) of 92.5% and worm expulsion rate (WER) of 88.4% for T. muris[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:4 week-old female C57BL/10 mice and 3 week-old male[1]
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Dosage:1 mg/kg, 2.5 mg/kg, 5 mg/kg, 10 mg/kg
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Administration:Intraperitoneal injection
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Result:Inhibited T. muris in vivo.
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS. Nr. 36531-26-7
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Molecular Weight 216.28
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Formel C13H16N2O
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SMILES
OC1=CC=CC(/C=C/C2=NCCCN2C)=C1
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Synonyms
CP-14445
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
[1]. Richard J Martin, et al. Oxantel is an N-type (methyridine and nicotine) agonist not an L-type (levamisole and pyrantel) agonist: classification of cholinergic anthelmintics in Ascaris. Int J Parasitol. 2004 Aug;34(9):1083-90. [Content Brief]
[2]. Dashper S, et al. Oxantel disrupts polymicrobial biofilm development of periodontal pathogens. Antimicrob Agents Chemother. 2014;58(1):378-85. [Content Brief]
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Oxantel Related Classifications
HY-124498 Related Classifications
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