Art. -Nr.: HY-N8698

Picein

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Picein is an antioxidant and anti-inflammatory agent. Picein can be isolated from the leaves of Picrorhiza kurroa. Picein reduces MDA levels and increases the levels of SOD, GPX and TAC. Picein alleviates oxidative stress and promotes bone regeneration in osteoporotic bone defects by inhibiting Ferroptosis (via activation of the Nrf2/HO-1/GPX4 pathway). Picein prevents scopolamine (HY-N0296)-induced passive avoidance memory impairment in rats. Picein can be used in research related to osteoporotic bone defects and Alzheimer's disease.

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Reinheit: 99.98%
CAS. Nr.: 530-14-3
Formel: C₁₄H₁₈O₇
Molecular Weight:298.29

Speicherung:

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Picein Chemical Structure

CAS. Nr.: 530-14-3

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Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- Cellular Effect
- In Vitro
- In Vivo
Chemical Information
Publications (1)
Lösungsmittel & Löslichkeit
- In Vitro
- In Vivo
Reinheit & Dokumentation
Verweise
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

IC₅₀ & Target^[1]

HO-1

GPX4

Alle Heme Oxygenase (HO) Isoform-spezifische Produkte anzeigen :

HO-1
HO-2

Alle Glutathione Peroxidase Isoform-spezifische Produkte anzeigen :

GPX1
GPX4

Cellular Effect

Cell Line	Type	Value	Description	References
HepG2 2.2.15	CC₅₀	>3947.9 μM Compound: 2	Cytotoxicity against human HepG 2.2.15 cells by MTT assay Cytotoxicity against human HepG 2.2.15 cells by MTT assay	[PMID: 25737008]
HepG2 2.2.15	IC₅₀	>3947.9 μM Compound: 2	Antiviral activity against hepatitis B viral in human HepG2.2.15 cells assessed as surface antigen HBeAg secretion after 72 hrs by ELISA Antiviral activity against hepatitis B viral in human HepG2.2.15 cells assessed as surface antigen HBeAg secretion after 72 hrs by ELISA	[PMID: 25737008]
HepG2 2.2.15	IC₅₀	>3947.9 μM Compound: 2	Antiviral activity against hepatitis B viral in human HepG2.2.15 cells assessed as surface antigen HBsAg secretion after 72 hrs by ELISA Antiviral activity against hepatitis B viral in human HepG2.2.15 cells assessed as surface antigen HBsAg secretion after 72 hrs by ELISA	[PMID: 25737008]
HepG2 2.2.15	IC₅₀	227.8 μM Compound: 2	Antiviral activity against hepatitis B viral in human HepG2.2.15 cells assessed as decrease in viral DNA replication treated for 7 days by real time PCR analysis Antiviral activity against hepatitis B viral in human HepG2.2.15 cells assessed as decrease in viral DNA replication treated for 7 days by real time PCR analysis	[PMID: 25737008]

In Vitro

Picein (10-80 μM; 24 h) shows no toxicity to rat bone marrow mesenchymal stem cells (BMSCs), and Picein (80 μM; 2 h pretreatment followed by 24, 48, 72 h erastin incubation) significantly restores the viability of rat BMSCs impaired by Erastin^[1].
Picein (80 μM) significantly restores the viability of HUVECs impaired by Erastin^[1].
Picein (80 μM; 48 h) significantly promotes M2 polarization of Raw 264.7 macrophages and reverses the inhibitory effect of 5 μM erastin^[1].
Picein (for 7-21 days) significantly reverses the inhibitory effect of 5 μM erastin on osteogenic differentiation of rat bone marrow mesenchymal stem cells (BMSCs), which is verified by increased alkaline phosphatase (ALP) activity, enhanced mineralization level, and upregulated expression of osteogenesis-related proteins and genes^[1].
Picein reduces ROS levels and restores mitochondrial function in neuroblastoma SH-SY5Y cells treated with Menadione (HY-B0332), indicating its potential as a neuroprotective agent^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Picein (40-80 mg/kg; topical to femoral condyle; daily; 4 weeks) promotes bone regeneration in ovariectomized rats with osteoporotic femoral condyle defects, with the 80 mg/kg dose yielding a 48% BV/TV, and reduces local and systemic inflammation by lowering IL-1β, IL-6, and TNF-α levels^[1].
Picein (1.25-5 mg/kg; i.c.v.; daily; 7 days), most potently at 2.5 mg/kg, reduces hippocampal oxidative stress, increases neuronal density, and reverses scopolamine-induced passive avoidance memory impairment in male Wistar rats^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS. Nr. 530-14-3
Appearance Solid
Molecular Weight 298.29
Formel C₁₄H₁₈O₇
Color Off-white to light yellow
SMILES

O[C@H]([C@H]([C@@H]([C@H](O1)CO)O)O)[C@@H]1OC2=CC=C(C=C2)C(C)=O
Structure Classification
- Saccharides
Initial Source
- Plants
- Nyssaceae
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Publications (1)

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Journal Impact Factor

Environ Toxicol

Picein alleviates oxidative stress and promotes bone regeneration in osteoporotic bone defect by inhibiting ferroptosis via Nrf2/HO-1/GPX4 pathway. [Abstract]

2024 May 10. PMID: 38727095

Lösungsmittel & Löslichkeit

In Vitro:

DMSO : 200 mg/mL (670.49 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

3.3524 mL

16.7622 mL

33.5244 mL

5 mM

0.6705 mL

3.3524 mL

6.7049 mL

10 mM

0.3352 mL

1.6762 mL

3.3524 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline

Solubility: ≥ 5 mg/mL (16.76 mM); Clear solution

This protocol yields a clear solution of ≥ 5 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (50.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)

Solubility: ≥ 5 mg/mL (16.76 mM); Clear solution

This protocol yields a clear solution of ≥ 5 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (50.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil

Solubility: ≥ 5 mg/mL (16.76 mM); Clear solution

This protocol yields a clear solution of ≥ 5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (50.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg
Animal Weight (Per Animal) Animal Weight (Per Animal)
g
Dosing Volume (Per Animal) Dosing Volume (Per Animal)
μL
Number of Animals Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

%
DMSO +

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
%
+
+
%
Tween-80 + +
%
Saline +

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Working solution concentration: 0.22 mg/mL

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (277 KB)
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Huang L, et al. Picein alleviates oxidative stress and promotes bone regeneration in osteoporotic bone defect by inhibiting ferroptosis via Nrf2/HO-1/GPX4 pathway. Environ Toxicol. 2024;39(7):4066-4085. [Content Brief]

[2]. Kant K, et al. Evaluation of Antioxidant Activity of Picrorhiza kurroa (Leaves) Extracts. Indian J Pharm Sci. 2013;75(3):324-329. [Content Brief]

[3]. Elyasi L, et al. The Effect of Picein on Inhibitory Avoidance Memory and Activity of Antioxidant Enzymes in Hippocampus of Male Rats with Scopolamine-Induced Injury. Mol Neurobiol. 2025;62(6):7835-7845. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	3.3524 mL	16.7622 mL	33.5244 mL	83.8111 mL
	5 mM	0.6705 mL	3.3524 mL	6.7049 mL	16.7622 mL
	10 mM	0.3352 mL	1.6762 mL	3.3524 mL	8.3811 mL
	15 mM	0.2235 mL	1.1175 mL	2.2350 mL	5.5874 mL
	20 mM	0.1676 mL	0.8381 mL	1.6762 mL	4.1906 mL
	25 mM	0.1341 mL	0.6705 mL	1.3410 mL	3.3524 mL
	30 mM	0.1117 mL	0.5587 mL	1.1175 mL	2.7937 mL
	40 mM	0.0838 mL	0.4191 mL	0.8381 mL	2.0953 mL
	50 mM	0.0670 mL	0.3352 mL	0.6705 mL	1.6762 mL
	60 mM	0.0559 mL	0.2794 mL	0.5587 mL	1.3969 mL
	80 mM	0.0419 mL	0.2095 mL	0.4191 mL	1.0476 mL
	100 mM	0.0335 mL	0.1676 mL	0.3352 mL	0.8381 mL

Picein

1 Cited Publications

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Picein

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Publications Citing Use of MedChemExpress (MCE) Picein

Alle Heme Oxygenase (HO) Isoform-spezifische Produkte anzeigen

Alle Glutathione Peroxidase Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Publications (1)

Lösungsmittel & Löslichkeit

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table

Picein Related Classifications

HY-N8698 Related Classifications