Piperilate
Piperilate (Pipethanate) is one of the mixtures of hetrazepine derivative PAF antagonists with anticholinergics, can be used for bronchial asthma research. Piperilate also causes hypotension and rescues mice poisoned by the organophosphates.
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- CAS. Nr.: 4546-39-8
- Formel: C21H25NO3
- Molecular Weight:339.43
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
Biologische Aktivität
Piperilate (1 mg/kg; i.v.) causes hypotension in rabbit which is not blocked by dichloroisoproterenol or Atropine (HY-B1205)[2].
Piperilate (3 mg/kg; i.v.) decreases respiration and heart rate of test rabbits, blocks the Adrenaline (HY-122304)-induced constriction of an isolated rabbit auricle preparation[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Male albino mice (18-22 g)[1]
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Dosage:11.3 mg/kg, 29.42 mg/kg
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Administration:Intraperitoneal injection; single dose
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Result:Showed anticholinergic activity with EC50 values of 11.33 mg/kg (antagonism of oxotremorine induced salivation) and 29.42 mg/kg (antagonism of oxotremorine induced tremor) in mice.
Chemical Information
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CAS. Nr. 4546-39-8
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Molecular Weight 339.43
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Formel C21H25NO3
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SMILES
O=C(OCCN1CCCCC1)C(C2=CC=CC=C2)(C3=CC=CC=C3)O
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Synonyms
Pipethanate
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
[1]. Faff J, et al. Therapeutic effects of some cholinolytics in organophosphate intoxications. Arch Toxicol. 1976 Oct 28;36(2):139-46. [Content Brief]
[2]. Tanaka S, et al. [Studies on pharmacological effect of pipethanate. II. Effect of pipethanate on respiration, circulation system and smooth muscle]. Eisei Shikenjo Hokoku. 1971;89:54-8. Japanese. [Content Brief]
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Piperilate Related Classifications
HY-105790 Related Classifications
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