PVZB1194
Based on 1 Customer Validation
PVZB1194 is a biphenyl-type inhibitor of Kinesin-5 ATPase activity that binds to the α4/α6 site of the motor domain in a nucleotide competitive manner. PVZB1194 has an IC50 of 0.12 μM for KSP ATPase. PVZB1194 induces mitotic arrest with the formation of a monopolar spindle, and inhibits HeLa cells proliferatio (IC50: 5.5 μM). PVZB1194 can be used in the study of tumors.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- Reinheit: 99.64%
- CAS. Nr.: 1141768-04-8
- Formel: C13H9F4NO2S
- Molecular Weight:319.27
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Speicherung:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biologische Aktivität
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Chemical Information
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Lösungsmittel & Löslichkeit
- Reinheit & Dokumentation
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Biologische Aktivität
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Eg5 |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HeLa | IC50 |
5.5 μM
Compound: 16, PVZB1194
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Cytotoxicity against human HeLa cells after 48 hrs by MTS assay
Cytotoxicity against human HeLa cells after 48 hrs by MTS assay
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[PMID: 19167222] |
PVZB1194 (1-5 nM; 24-72 h) inhibits cell proliferation and induces mitotic arrest in a concentration-dependent manner in HeLa cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS. Nr. 1141768-04-8
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Appearance Solid
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Molecular Weight 319.27
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Formel C13H9F4NO2S
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Color White to off-white
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SMILES
O=S(C1=CC=C(C2=CC=C(C(F)(F)F)C(F)=C2)C=C1)(N)=O
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Lösungsmittel & Löslichkeit
DMSO : 250 mg/mL (783.04 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Reinheit & Dokumentation
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Data Sheet (272 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
Verweise
[1]. Sawada JI, et al. Various effects of two types of kinesin-5 inhibitors on mitosis and cell proliferation. Biochem Pharmacol. 2021 Nov;193:114789. [Content Brief]
[2]. Matsuno K, et al. Bis(hetero)aryl derivatives as unique kinesin spindle protein inhibitors. Bioorg Med Chem Lett. 2009 Feb 15;19(4):1058-61. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.1321 mL | 15.6607 mL | 31.3215 mL | 78.3036 mL |
| 5 mM | 0.6264 mL | 3.1321 mL | 6.2643 mL | 15.6607 mL | |
| 10 mM | 0.3132 mL | 1.5661 mL | 3.1321 mL | 7.8304 mL | |
| 15 mM | 0.2088 mL | 1.0440 mL | 2.0881 mL | 5.2202 mL | |
| 20 mM | 0.1566 mL | 0.7830 mL | 1.5661 mL | 3.9152 mL | |
| 25 mM | 0.1253 mL | 0.6264 mL | 1.2529 mL | 3.1321 mL | |
| 30 mM | 0.1044 mL | 0.5220 mL | 1.0440 mL | 2.6101 mL | |
| 40 mM | 0.0783 mL | 0.3915 mL | 0.7830 mL | 1.9576 mL | |
| 50 mM | 0.0626 mL | 0.3132 mL | 0.6264 mL | 1.5661 mL | |
| 60 mM | 0.0522 mL | 0.2610 mL | 0.5220 mL | 1.3051 mL | |
| 80 mM | 0.0392 mL | 0.1958 mL | 0.3915 mL | 0.9788 mL | |
| 100 mM | 0.0313 mL | 0.1566 mL | 0.3132 mL | 0.7830 mL |
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