(R)-ACBI-4
(R)-ACBI-4 is an isomer of ACBI-4 (HY-176792). ACBI-4 is a selective GTP-loaded active state of KRAS (KRAS(on)) PROTAC degrader. ACBI-4 has significant anti-proliferative effect and potently degrades multiple KRAS mutants in cancer cells, such as KRASG12R.
(Pink: Ras ligand (HY-162960); Blue: VHL ligand (HY-176917); Black: linker).
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- CAS. Nr.: 3097973-97-9
- Formel: C50H63N15O4S
- Molecular Weight:970.20
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
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Biologische Aktivität
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VHL |
K-RAS |
Chemical Information
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CAS. Nr. 3097973-97-9
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Molecular Weight 970.20
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Formel C50H63N15O4S
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SMILES
CC([C@H](N1N=NC2=C1CC[C@@H](CCCN3C[C@@H](N(CCC3)C4=NC(C5=NOC([C@@]6(C7=C(CCC6)SC(N)=C7C#N)C)=N5)=CC=N4)C)C2)C(N8C[C@@H](C[C@H]8C(NCC9=CC=C%10C(N(N=C%10)C)=C9)=O)O)=O)C
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
(R)-ACBI-4 Related Classifications
HY-176792A Related Classifications
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