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Art. -Nr.: HY-187736

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R34803

R34803 is an orally effective Microtubule inhibitor and antiparasitic agent. R34803 impedes directional migration by interfering with the cytoplasmic microtubule complex, and causes metaphase arrest to inhibit the growth of cancer cell aggregates while preventing their invasion into other tissues. R34803 exhibits activity against a variety of parasites. R34803 can be used for research on fibrosarcoma and helminthiasis.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

CAS. Nr.: 64420-40-2
Formel: C₁₈H₁₆FN₃O₄
Molecular Weight:357.34

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

R34803 Chemical Structure

CAS. Nr.: 64420-40-2

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- In Vitro
Chemical Information
Protokoll (2)
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

Alle Parasite Isoform-spezifische Produkte anzeigen :

In Vitro

R34803 (1 μg/mL; 2-7 days) prevents invasion of MO₄ mouse fibrosarcoma cells into embryonic chick heart tissue and inhibits growth of the confronting tissues without causing central necrosis^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.

Cell Invasion Assay^[1]

View Protocol

Cell Line:

MO₄ mouse fibrosarcoma cell line
Concentration:

1 μg/mL
Incubation Time:

2, 4, 7 days
Result:

Prevented invasion of MO₄ cells into embryonic chick heart tissue.
Inhibited growth of confronting tissues.
Did not cause central necrosis.

Chemical Information

CAS. Nr. 64420-40-2
Molecular Weight 357.34
Formel C₁₈H₁₆FN₃O₄
SMILES

O=C(OC)NC1=NC=2C=CC(=CC2N1)C3(OCCO3)C4=CC=C(F)C=C4
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Protokoll

All Cell Biology

Cell migration
Cell migration is a method that plays an important role in wound healing, cell differentiation, embryonic development, etc.
Cell invasion
Cell invasion is the ability of cells to migrate from one area to another via the extracellular matrix. Cell invasion is the response of normal and cancer cells to chemical and mechanical stimuli. Before migrating to a new region, the extracellular matrix is degraded by proteases within the cell. Cell invasion often occurs during wound repair, vascularization and inflammation, abnormal tissue invasion, and tumor cell metastasis.

Reinheit & Dokumentation

Handling Instructions (2659 KB)

Verweise

[1]. Storme G, et al. Effect of anticancer agents on invasion of mouse fibrosarcoma cells in vitro. Oncology. 1981;38(3):182-6.

[2]. Restrepo M, et al. Evaluación del R-34803 en el tratamiento de helmintiasis. Acta Med Colomb. 1983;8(4):224-27.

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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