Art. -Nr.: HY-Y1094

[Rh(cod)Cl]2

Name: [Rh(cod)Cl]2
Brand: MedChemExpress
SKU: HY-Y1094
Price: 89.00 USD
Availability: InStock
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(Synonyms: Chloro(1,5-cyclooctadiene)rhodium(I) dimer)

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[Rh(cod)Cl]2 (Chloro (1,5-cyclooctadiene) rhodium (I) dimer) is an organometallic rhodium (I) dimer precursor and platelet aggregation inhibitor. [Rh(cod)Cl]2 inhibits PAF-induced aggregation in washed rabbit platelets. [Rh(cod)Cl]2 inhibits aggregation induced by PAF, Thrombin, ADP and Collagen in human platelet-rich plasma. [Rh(cod)Cl]2 acts as a catalyst precursor for the hydrogenation of aromatic hydrocarbons, phenols, olefins and BINOL derivatives. [Rh(cod)Cl]2 is used in the research of cardiovascular diseases such as thromboinflammation-related disorders, tumor metastasis and atherosclerosis.

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Reinheit : 99.91%
CAS. Nr.: 12092-47-6
Formel: C₁₆H₂₄Cl₂Rh₂
Molecular Weight:493.08

Speicherung:

4°C, protect from light, stored under nitrogen

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

[Rh(cod)Cl]2 Chemical Structure

CAS. Nr.: 12092-47-6

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Biologische Aktivität
- Beschreibung
- In Vitro
Chemical Information
Lösungsmittel & Löslichkeit
- In Vitro
- In Vivo
Protokoll (2)
Reinheit & Dokumentation
Verweise
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

In Vitro

[Rh(cod)Cl]2 inhibits washed rabbit platelet aggregation induced by platelet-activating factor (PAF), with an IC₅₀ of 5.2 μM^[1].
[Rh(cod)Cl]2 inhibits PAF-induced aggregation of human platelet-rich plasma, with an IC₅₀ of 43.3 μM^[1].
[Rh(cod)Cl]2 inhibits thrombin (HY-114164)-induced aggregation of human platelet-rich plasma with an IC₅₀ of 16.7 μM^[1].
[Rh(cod)Cl]2 inhibits ADP (HY-W010918)-induced aggregation of human platelet-rich plasma with an IC₅₀ of 162 μM^[1].
[Rh(cod)Cl]2 inhibits collagen (HY-NP003)-induced aggregation of human platelet-rich plasma, with an IC₅₀ of 69.8 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.

Chemical Information

CAS. Nr. 12092-47-6
Appearance Solid
Molecular Weight 493.08
Formel C₁₆H₂₄Cl₂Rh₂
Color Yellow to orange
SMILES

C1=C\CC/C=C\CC/1.C2/C=C\CC/C=C\C2.[Rh]3[ClH][Rh][ClH]3
Synonyms

Chloro(1,5-cyclooctadiene)rhodium(I) dimer
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

4°C, protect from light, stored under nitrogen

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

Lösungsmittel & Löslichkeit

In Vitro:

DMSO : 50 mg/mL (101.40 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

2.0281 mL

10.1403 mL

20.2807 mL

5 mM

0.4056 mL

2.0281 mL

4.0561 mL

10 mM

0.2028 mL

1.0140 mL

2.0281 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)

Solubility: 2.5 mg/mL (5.07 mM); Suspended solution; Need ultrasonic

This protocol yields a suspended solution of 2.5 mg/mL. Suspended solution can be used for oral and intraperitoneal injection.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg
Animal Weight (Per Animal) Animal Weight (Per Animal)
g
Dosing Volume (Per Animal) Dosing Volume (Per Animal)
μL
Number of Animals Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

%
DMSO +

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
%
+
+
%
Tween-80 + +
%
Saline +

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Working solution concentration: 0.22 mg/mL

Protokoll

All Signal Pathway Related Animals and Diseases

Research Protocol for Cardiovascular Diseases
Cardiovascular disease can be modeled as maladaptive cardiac remodeling, where ischemic injury or pressure overload activates inflammatory signaling, fibroblast activation, extracellular-matrix deposition, cardiomyocyte hypertrophy, vascular remodeling, and progressive ventricular dysfunction. The TGF-β/SMAD axis is a central profibrotic pathway after myocardial injury and pressure overload, while innate immune and cytokine pathways regulate leukocyte recruitment, scar formation, and adverse remodeling. Key unresolved questions include which inflammatory signals are reparative versus harmful, when fibrosis is protective versus maladaptive, and whether pathway inhibition improves function without weakening necessary infarct healing or compensatory remodeling.
Orthotopic Cell-Line Xenograft
Orthotopic cell-line xenograft models involve implantation of human cancer cell lines into the anatomically corresponding organ of immunodeficient mice to reproduce tumor growth within a native microenvironment, enabling more clinically relevant tumor behavior compared with subcutaneous models. These models are widely used because orthotopic placement better recapitulates tumor progression, including invasion and metastatic spread, which are often underrepresented in heterotopic implantation systems. Compared with conventional xenografts, orthotopic implantation is described as more technically complex but provides improved simulation of tumor-microenvironment interactions and metastatic behavior, making it particularly valuable for translational oncology research. Surgical orthotopic implantation approaches have been emphasized as enabling faithful reproduction of clinical cancer features, including metastasis and disease progression patterns that align with the tumor’s organ of origi

Reinheit & Dokumentation

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Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (276 KB)
SDS (396 KB)
- English - EN (396 KB)
- Français - FR (396 KB)
- Deutsch - DE (396 KB)
- Norwegian - NO (396 KB)
- Español - ES (396 KB)
- Swedish - SV (396 KB)
- Italian - IT (396 KB)
- Korean - KR (396 KB)
- Portuguese - PT (396 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Kalampalidis A, et al. Antithrombotic and antiplatelet activity of an organometallic rhodium (I) complex incorporating a substituted thieno‐[2, 3‐d]‐pyrimidine ligand: Synthesis, structural characterization, and molecular docking calculations. Applied Organometallic Chemistry. 2021 Jun;35(6):e6210.

[2]. Wang DW, et al. A simple and highly effective method for hydrogenation of arenes by [Rh (COD) Cl] 2. Tetrahedron Letters. 2009 Mar 25;50(12):1282-5.

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	2.0281 mL	10.1403 mL	20.2807 mL	50.7017 mL
	5 mM	0.4056 mL	2.0281 mL	4.0561 mL	10.1403 mL
	10 mM	0.2028 mL	1.0140 mL	2.0281 mL	5.0702 mL
	15 mM	0.1352 mL	0.6760 mL	1.3520 mL	3.3801 mL
	20 mM	0.1014 mL	0.5070 mL	1.0140 mL	2.5351 mL
	25 mM	0.0811 mL	0.4056 mL	0.8112 mL	2.0281 mL
	30 mM	0.0676 mL	0.3380 mL	0.6760 mL	1.6901 mL
	40 mM	0.0507 mL	0.2535 mL	0.5070 mL	1.2675 mL
	50 mM	0.0406 mL	0.2028 mL	0.4056 mL	1.0140 mL
	60 mM	0.0338 mL	0.1690 mL	0.3380 mL	0.8450 mL
	80 mM	0.0254 mL	0.1268 mL	0.2535 mL	0.6338 mL
	100 mM	0.0203 mL	0.1014 mL	0.2028 mL	0.5070 mL

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[Rh(cod)Cl]2