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Art. -Nr.: HY-10563

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Sarpogrelate

(Synonyms: MCI-9042 free acid)

1 Cited Publications

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Based on 1 publication(s) in Google Scholar

Sarpogrelate (MCI-9042) is a new, specific orally active 5-HT₂ receptor antagonist, Sarpogrelate increases platelet aggregation and has hemostasis effect, and can be used for the research of Buerger’s disease.

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CAS. Nr.: 125926-17-2
Formel: C₂₄H₃₁NO₆
Molecular Weight:429.51

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Data Sheet (272 KB)

Sarpogrelate Chemical Structure

CAS. Nr.: 125926-17-2

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Biologische Aktivität

Beschreibung

IC₅₀ & Target

5-HT₂ Receptor

Alle 5-HT Receptor Isoform-spezifische Produkte anzeigen :

In Vitro

Sarpogrelate (MCI-9042) induces a significant decrease in plasma serotonin (5-HT) concentration and after 2 weeks increases significantly the concentration of whole blood 5-HT^[1].
Sarpogrelate increases significantly plasma tryptophan concentration after 2 and 4 weeks, and no changes in plasma 5-HIAA concentration^[1].
Sarpogrelate also has a tendency to increase the concentration of whole blood tryptophan concentration, did not show significant changes in platelet aggregation induced by ADP and collagen^[1].
Sarpogrelate increases significantly platelet aggregation induced by serotonin after 2 weeks^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial

NCT Number	Sponsor	Condition	Start Date	Phase A549
NCT01329991	Plexxikon\|		2011-05	PHASE1

Chemical Information

CAS. Nr. 125926-17-2
Molecular Weight 429.51
Formel C₂₄H₃₁NO₆
SMILES

COC1=CC=CC(CCC2=CC=CC=C2OCC(CN(C)C)OC(CCC(O)=O)=O)=C1
Synonyms

MCI-9042 free acid
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Publications (1)

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Exp Neurol

Reduced serotonin impairs long-term depression in basolateral amygdala complex and causes anxiety-like behaviors in a mouse model of perimenopause. [Abstract]

2019 Nov:321:113030. PMID: 31377402

Reinheit & Dokumentation

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Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (272 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. A Rydzewski, et al. The effect of a 5HT2 receptor antagonist sarpogrelate (MCI-9042) treatment on platelet function in Buerger's disease. Thromb Res. 1996 Dec 15;84(6):445-52. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

Sarpogrelate

1 Cited Publications

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Sarpogrelate

Publications Citing Use of MedChemExpress (MCE) Sarpogrelate

Alle 5-HT Receptor Isoform-spezifische Produkte anzeigen

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Publications (1)

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Sarpogrelate Related Classifications

HY-10563 Related Classifications