SKF 83822
Based on 1 publication(s) in Google Scholar
SKF 83822 is an atypical agonist of dopamine D1 receptor. SKF 83822 activates adenylyl cyclase (AC), but not phospholipase C (PLC). SKF 83822 is also proved to stimulate AC via cAMP production. SKF 83822 can be used for research of schizophrenia.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- Reinheit: 98.01%
- CAS. Nr.: 74115-08-5
- Formel: C20H22ClNO2
- Molecular Weight:343.85
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Speicherung:
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
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Biologische Aktivität
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Chemical Information
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Lösungsmittel & Löslichkeit
- Reinheit & Dokumentation
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Publications Citing Use of MedChemExpress (MCE) SKF 83822
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Biologische Aktivität
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Rat D1 Receptor |
SKF 83822 shows significant effects in a moderate and high dose with 0.25 mg/kg and 0.35 mg/kg, respectively, in monkeys. And it (0.15-0.35 mg/kg; s.c.; single dose) induces locomotion but nor inducing dyskinesia. SKF 83822 results in a state of extreme arousal and locomotor activation without stereotypy[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Adult, male Sprague-Dawley derived rats[1]
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Dosage:6.25 μg/kg, 25 μg/kg, 50 μg/kg, and 100 μg/kg; with or without 0.5 mg/kg antagonist SCH 23390.
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Administration:SC; single dose, 30 min after antagonist treatment.
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Result:Produced a strong rotational response at 50 μg/kg which was approximately midway between that produced by the 25 and 100 μg/kg doses in the first experiment.
Could be inhibited by antagonist of dopamine D1 receptor, SCH 23390.
Chemical Information
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CAS. Nr. 74115-08-5
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Appearance Solid
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Molecular Weight 343.85
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Formel C20H22ClNO2
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Color Light yellow to yellow
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SMILES
OC1=C(C=C2C(CN(CCC2=C1Cl)CC=C)C3=CC=CC(C)=C3)O
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Publications (1)
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Journal Impact Factor
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Most Recent
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J Neurosci
Acute Ongoing Nociception Delays Recovery of Consciousness from Sevoflurane Anesthesia via a Midbrain Circuit. [Abstract]2024 Jul 17:e0740242024. PMID: 39019613
Lösungsmittel & Löslichkeit
DMSO : 100 mg/mL (290.82 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Reinheit & Dokumentation
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Data Sheet (278 KB)
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SDS (564 KB)
- English - EN (564 KB)
- Français - FR (564 KB)
- Deutsch - DE (564 KB)
- Norwegian - NO (564 KB)
- Español - ES (564 KB)
- Swedish - SV (564 KB)
- Italian - IT (564 KB)
- Korean - KR (564 KB)
- Portuguese - PT (564 KB)
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Handling Instructions (2659 KB)
Verweise
[1]. Wirtshafter D. Rotation and immediate-early gene expression in rats treated with the atypical D1 dopamine agonist SKF 83822. Pharmacol Biochem Behav. 2007 Mar;86(3):505-10. [Content Brief]
[2]. Peacock L, et al. Aberrant behavioral effects of a dopamine D1 receptor antagonist and agonist in monkeys: evidence of uncharted dopamine D1 receptor actions. Biol Psychiatry. 2001 Oct 1;50(7):501-9. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.9082 mL | 14.5412 mL | 29.0824 mL | 72.7061 mL |
| 5 mM | 0.5816 mL | 2.9082 mL | 5.8165 mL | 14.5412 mL | |
| 10 mM | 0.2908 mL | 1.4541 mL | 2.9082 mL | 7.2706 mL | |
| 15 mM | 0.1939 mL | 0.9694 mL | 1.9388 mL | 4.8471 mL | |
| 20 mM | 0.1454 mL | 0.7271 mL | 1.4541 mL | 3.6353 mL | |
| 25 mM | 0.1163 mL | 0.5816 mL | 1.1633 mL | 2.9082 mL | |
| 30 mM | 0.0969 mL | 0.4847 mL | 0.9694 mL | 2.4235 mL | |
| 40 mM | 0.0727 mL | 0.3635 mL | 0.7271 mL | 1.8177 mL | |
| 50 mM | 0.0582 mL | 0.2908 mL | 0.5816 mL | 1.4541 mL | |
| 60 mM | 0.0485 mL | 0.2424 mL | 0.4847 mL | 1.2118 mL | |
| 80 mM | 0.0364 mL | 0.1818 mL | 0.3635 mL | 0.9088 mL | |
| 100 mM | 0.0291 mL | 0.1454 mL | 0.2908 mL | 0.7271 mL |
SKF 83822 Related Classifications
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