UC-857993
UC-857993 is a selective SOS1-Ras inhibitor (Kd=14.7 μM, His6-SOS1cat), suppressing catalytic activity. UC-857993 also inhibits ERK and Ras activation, suppresses the growth of mouse embryonic fibroblasts (MEFs).
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- CAS. Nr.: 487001-04-7
- Formel: C25H22ClNO2
- Molecular Weight:403.90
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
Biologische Aktivität
UC-857993 (0-80 μM; 3 d) specifically inhibits the growth of wild-type MEFs, but did not inhibit the growth of carcinogenic H-Ras(G12V) expressing MEF[1].
UC-857993 (60 μM, 80 μM; 2 h) dose-dependently inhibits Ras activation and downstream ERK activation mediated through EGFR-SOS1-Ras-Raf1-MEK-ERK signaling[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Mouse embryonic fibroblasts
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Concentration:0, 40, 60, and 80 μ M
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Incubation Time:3 days
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Result:Selectively inhibited the growth of mouse fibroblasts, as exerting inhibition against wild-type mouse embryonic fibroblasts but not mouse embryonic fibroblasts expressing carcinogenic H-Ras(G12V).
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Cell Line:NIH/3T3 cells
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Concentration:60 μM, 80 μM
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Incubation Time:2 hours; stimulated with 50 ng/ml EGF for 5 min
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Result:Inhibited EGF-induced the increase of the level of p-ERK and Ras-GTP.
Chemical Information
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CAS. Nr. 487001-04-7
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Molecular Weight 403.90
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Formel C25H22ClNO2
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SMILES
O=C(C1=CC2=C3N(C(C4=CC=CC=C4Cl)C5C2C=CC5)CC(CC=C6)C6C3=C1)O
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
UC-857993 Related Classifications
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