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UCUF-965

UCUF-965 is a CXCR4 positive allosteric modulator. UCUF-965 potentiates CXCL12-induced β-arrestin recruitment and cAMP signaling, activates lymphoblast migration, induces calcium flux, and does not bind CXCR4’s orthosteric CXCL12 site. UCUF-965 reduces miR-15b and miR-29a levels, increases miR-146a levels in fibroblasts. UCUF-965 enhances angiogenesis and reduces wound healing time in diabetic mice. UCUF-965 can be used for the research of diabetic wound healing impairment.

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CAS. Nr.: 2965316-77-0
Formel: C₂₂H₂₃N₅OS
Molecular Weight:405.52

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

UCUF-965 Chemical Structure

CAS. Nr.: 2965316-77-0

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Bioz

Biologische Aktivität

Beschreibung

IC₅₀ & Target^[1]

CXCR4

Alle CXCR Isoform-spezifische Produkte anzeigen :

In Vitro

UCUF-965 (0.1-10 μM) promotes β-arrestin recruitment with an EC₅₀ of 0.02 μM^[1].
UCUF-965 acts as a partial agonist of CXCR4-mediated cAMP inhibition in CXCR4-overexpressing CHO cells, with an EC₅₀ of 0.05 μM^[1].
UCUF-965 (0.4 μM; 3 h) induces migration of CEM-CCRF human lymphoblast cells via CXCR4 activation, with an EC₅₀ of 0.4 μM^[1].
UCUF-965 (10 μM) induces CXCR4-mediated calcium flux in CEM-CCRF human lymphoblast cells^[1].
UCUF-965 (0.1-10 μM; 24 h) modulates the expression of wound healing-related microRNAs in murine diabetic and non-diabetic fibroblasts, reducing miR-15b and miR-29a levels and increasing miR-146a levels^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Migration Assay ^[1]

Cell Line:

CEM-CCRF human lymphoblast cells
Concentration:

0.4 μM
Incubation Time:

3 h
Result:

Induced CEM-CCRF cell migration with an EC₅₀ of 0.4 μM and an average Eₘₐₓ of 31%.

Real Time qPCR^[1]

Cell Line:

murine diabetic (Db/Db) fibroblasts; murine non-diabetic (HZ) fibroblasts
Concentration:

0.1, 1, 10 μM
Incubation Time:

24 h
Result:

Decreased the expression of miR-15b in both diabetic and non-diabetic fibroblasts in a dose-dependent manner.
Decreased miR-29a levels and increased miR-146a levels in both cell types, with responses observed at concentrations as low as 0.1 μM.

In Vivo

UCUF-965 (10 μM; intradermal injection; single dose) reduces diabetic wound healing time by 36% and enhances angiogenesis in diabetic mice^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Db/Db mice (10-week-old female, diabetic model)^[1]
Dosage:

10 μM
Administration:

intradermal injection; single dose (immediately after wounding)
Result:

Reduced wound surface area compared to controls starting at post-injury day 6.
Achieved full wound closure at day 14, representing a 36% reduction in wound healing time compared to day 22 in PBS-treated controls.
Showed a significant increase in CD31-positive endothelial cells at day 7 post-wounding, reaching levels similar to non-diabetic control wounds.

Chemical Information

CAS. Nr. 2965316-77-0
Molecular Weight 405.52
Formel C₂₂H₂₃N₅OS
SMILES

N=1N=C(C=2C=CC=CC2OCC)N3N=C(C=4C=CC(=CC4)N5CCCC5)CSC13
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Handling Instructions (2659 KB)

Verweise

[1]. Peddibhotla S, et al. Triazolothiadiazine derivative positively modulates CXCR4 signaling and improves diabetic wound healing. Biochem Pharmacol. 2023;216:115764. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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