YM-344031
YM-344031 is an orally active antagonist for CCR3. YM-344031 inhibits binding of Eotaxin-1 and RANTES to CCR3, with IC50 of 3.0 and 16.3 nM. YM-344031 inhibits ligand-induced rise in intracellular Ca[2+] and the ligand-induced chemotaxis. YM-344031 inhibits eotaxin-1-induced changes in eosinophil morphology in macaques blood, and prevents allergic skin reactions in a mouse allergy model.
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- CAS. Nr.: 671204-98-1
- Formel: C29H31FN4O3
- Molecular Weight:502.58
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Chemical Information
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Biologische Aktivität
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CCR3 |
Chemical Information
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CAS. Nr. 671204-98-1
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Molecular Weight 502.58
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Formel C29H31FN4O3
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SMILES
FC(C=C1)=CC(C=C2)=C1C=C2CN3C[C@@H](CC3)NC(/C=C4CCN(CC/4)C(C5=C(C=CC=[N+]5[O-])C)=O)=O
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
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