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Cat. No.: HY-124938

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ABC-1

ABC-1 is a phosphorylated analogue and a potential antiviral agent against Newcastle disease virus (NDV). ABC-1 has potent antiviral activity.

For research use only. We do not sell to patients.

CAS No.: 309735-05-5
Formula: C₁₆H₁₆N₂OS
Molecular Weight:284.38

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (268 KB)

ABC-1 Chemical Structure

CAS No.: 309735-05-5

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

ABC-1 is a phosphorylated analogue and a potential antiviral agent against Newcastle disease virus (NDV). ABC-1 has potent antiviral activity^[1]^[2].

All Antibiotic Isoforms :

In Vitro

ABC-1 (175 and 350 μM; 96 hours) potently inhibits Cytopathic effect (CPE) ^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cytotoxicity Assay^[1]

Cell Line:

DF-1 cells
Concentration:

175 and 350 μM
Incubation Time:

96 hours
Result:

Inhibits Cytopathic effect (CPE).

In Vivo

ABC-1 (2 mg/kg; Oral) reduces colocalized cells in liver and clara cells in lung tissue when compared to NDV control animals^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Chickens (NDV treated) ^[2]
Dosage:

2 mg/kg
Administration:

Oral
Result:

Reduced colocalized cells in liver and clara cells in lung tissue when compared to NDV control animals.

Chemical Information

CAS No. 309735-05-5
Molecular Weight 284.38
Formula C₁₆H₁₆N₂OS
SMILES

CC1=CC=C(CSC2=NC3=CC=C(OC)C=C3N2)C=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (268 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. K A S, et al. Design, Synthesis and Biological Evaluation of Novel Phosphorylated Abacavir Derivatives as Antiviral Agents Against Newcastle Disease Virus Infection in Chicken. Appl Biochem Biotechnol. 2016;180(2):361-381. [Content Brief]

[2]. Suresh KA, et al. Phosphorylated abacavir analogue (ABC-1) has ameliorative action against Newcastle disease virus induced pathogenesis in chicken. Biotechnol Appl Biochem. 2019;66(6):977-989. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
- Description
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References

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ABC-1

All Antibiotic Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

ABC-1 Related Classifications

HY-124938 Related Classifications