KW-8232
Based on 1 Customer Validation
KW-8232, an orally active anti-osteoporotic agent, and can reduces the biosynthesis of PGE2.
For research use only. We do not sell to patients.
- Purity: 98.10%
- CAS No.: 217813-15-5
- Formula: C37H41ClN4O6S
- Molecular Weight:705.26
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Storage:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
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EP |
KW-8232 is an anti-osteoporotic agent. KW-8232 reduces the biosynthesis of PGE2 in mouse osteoblastic cells[1].
KW-8232 possesses anti-viral activity against SARS-CoV-2 (EC50 ~1.2 μM )[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:male Sprague-Dawley rats (5-week-old)[1].
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Dosage:1, 3, 10, and 30 mg/kg.
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Administration:Orally once daily beginning 1 day prior to neurectomy for 28 days.
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Result:Decreased urinary calcium excreation in the neurectomized rats only at 30 mg/kg.
Chemical Information
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CAS No. 217813-15-5
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Appearance Solid
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Molecular Weight 705.26
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Formula C37H41ClN4O6S
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Color White to pink
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SMILES
O=C(N1CCN(CC1)C2=C(Cl)C=CC=C2)C3=C(C(C4=CC=C(C=C4)O)C5=CC=C(C=C5)O)C6=C(N3CCN(C)C)C=CC=C6.O=S(O)(C)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
DMSO : 125 mg/mL (177.24 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL. * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation
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Data Sheet (280 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.4179 mL | 7.0896 mL | 14.1792 mL | 35.4479 mL |
| 5 mM | 0.2836 mL | 1.4179 mL | 2.8358 mL | 7.0896 mL | |
| 10 mM | 0.1418 mL | 0.7090 mL | 1.4179 mL | 3.5448 mL | |
| 15 mM | 0.0945 mL | 0.4726 mL | 0.9453 mL | 2.3632 mL | |
| 20 mM | 0.0709 mL | 0.3545 mL | 0.7090 mL | 1.7724 mL | |
| 25 mM | 0.0567 mL | 0.2836 mL | 0.5672 mL | 1.4179 mL | |
| 30 mM | 0.0473 mL | 0.2363 mL | 0.4726 mL | 1.1816 mL | |
| 40 mM | 0.0354 mL | 0.1772 mL | 0.3545 mL | 0.8862 mL | |
| 50 mM | 0.0284 mL | 0.1418 mL | 0.2836 mL | 0.7090 mL | |
| 60 mM | 0.0236 mL | 0.1182 mL | 0.2363 mL | 0.5908 mL | |
| 80 mM | 0.0177 mL | 0.0886 mL | 0.1772 mL | 0.4431 mL | |
| 100 mM | 0.0142 mL | 0.0709 mL | 0.1418 mL | 0.3545 mL |
KW-8232 Related Classifications
HY-100304A Related Classifications
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