Cat. No.: HY-N0502

Mogroside V

5 Cited Publications

Customer Review

Based on 5 publication(s) in Google Scholar

Mogroside V is a the major active constituent of a traditional Chinese medicine Siraitiae Fructus. Mogroside V reduces the intracellular reactive oxygen species (ROS) levels and enhances mitochondrial function. Mogroside V has anti-oxidative, anti-diabetic and anti-carcinogenic effects. Mogroside V can be used for diabetic diseases research.

For research use only. We do not sell to patients.

Purity: 99.76%
CAS No.: 88901-36-4
Formula: C₆₀H₁₀₂O₂₉
Molecular Weight:1287.43

Storage:

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Mogroside V Chemical Structure

CAS No.: 88901-36-4

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
- In Vivo
Chemical Information
Publications (5)
Solvent & Solubility
- In Vitro
- In Vivo
Purity & Documentation
References
Help & FAQs
Classifications
Bioz

Biological Activity

Description

In Vitro

Mogroside V (20 μM, 40 h) reducs the ROS levels in in vitro maturation (IVM) oocytes^[1].
Mogroside V (20 μM, 40 h) can enhance mitochondrial function in oocytes^[1].
Mogroside V (1-250 μM, 24 h) promots apoptosis and cell cycle arrest of pancreatic cancer cells (PANC-1 cells) and may be mediated through regulating the STAT3 signaling pathway^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Immunofluorescence^[1]

Cell Line:

IVM oocytes
Concentration:

20 μM
Incubation Time:

40 h
Result:

Increased the fluorescence intensity compared to control group.
Increased the red/green fluorescence intensity ratio compared to control group.

Real Time qPCR^[1]

Cell Line:

IVM oocytes
Concentration:

20 μM
Incubation Time:

40 h
Result:

Increased the relative mRNA expression of SOD, CAT, PGC-1α and TFAM than in control group.

Cell Viability Assay^[3]

Cell Line:

PANC-1 cells
Concentration:

1-250 μM
Incubation Time:

24 h
Result:

Increased the percentage of TUNEL-positive cells ranging from 2.91% to 92.25%.

Apoptosis Analysis^[3]

Cell Line:

PANC-1 cells
Concentration:

1-250 μM
Incubation Time:

24 h
Result:

Induced apoptosis in PANC-1 cells in a concentration- and time-dependent manner

Western Blot Analysis^[3]

Cell Line:

PANC-1 cells
Concentration:

0-250 μM
Incubation Time:

24 h
Result:

Increased the expression of the cyclin kinase inhibitors CDKN1A (p21^WAF1) and CDKN1B (p27) in a dose-dependent manner.
Decreased the the expression of the pro-proliferative cell cycle regulators CCND1 (cyclin D1), CCNE1 (cyclin E1) and CDK2.
Suppressed phosphorylation of the kinases upstream of STAT3, including that of JAK2 and TYK2.

In Vivo

Mogroside V (100 mg/kg for Oral administration) transforms to 26 metabolites by the process of dehydrogenation, deoxidation, oxidation and isomerization in type 2 diabetes (T2D) model rats^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

T2D model rats^[2]
Dosage:

100 mg/kg
Administration:

Oral gavage (p.o.)
Result:

Detected 28 metabolites of mogroside V compared to the blank biological samples.
Displayed larger peak areas of metabolites in T2D rat plasma samples than those in healthy sample.

Chemical Information

CAS No. 88901-36-4
Appearance Solid
Molecular Weight 1287.43
Formula C₆₀H₁₀₂O₂₉
Color White to off-white
SMILES

C[C@@]([C@@](CC[C@H](O[C@]([C@@H]([C@@H](O)[C@@H]1O)O)([H])O[C@@H]1CO[C@@H]([C@@H]([C@@H](O)[C@@H]2O)O)O[C@@H]2CO)C3(C)C)([H])C3=CC4)([C@@H](C[C@@]56C)O)[C@]4([H])[C@@]5(CC[C@]6([H])[C@H](C)CC[C@H](C(C)(O)C)O[C@H](O[C@H](CO[C@@H]([C@@H]([C@@H](O)[C@@H]7O)O)O[C@@H]7CO)[C@@H](O)[C@@H]8O)[C@@H]8O[C@]([C@@H]([C@@H](O)[C@@H]9O)O)([H])O[C@@H]9CO)C
Structure Classification
- Terpenoids
- Triterpenes
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Publications (5)

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Journal Impact Factor

Phytomedicine

Fangchinoline suppresses nasopharyngeal carcinoma progression by inhibiting SQLE to regulate the PI3K/AKT pathway dysregulation. [Abstract]

2025 May:140:156484. PMID: 40090046
Cells

Identification of Natural Compounds Triggering MRGPRX2-Mediated Calcium Flux and Degranulation in RBL-2H3 Cells. [Abstract]

2026 Feb 3;15(3):287. PMID: 41677650
Mol Neurobiol

Mogroside V Ameliorates Spinal Cord Injury by Inhibiting M1 Microglia Polarization. [Abstract]

2025 Nov 26;63(1):181. PMID: 41296106
J Food Meas Charact

2026 Jan 23.
Biochem Biophys Res Commun

Mogroside V alleviates diquat-induced renal tubular epithelial cell injury via the TUG1/miR-29-3p/SIRT1 axis. [Abstract]

2026 May 7:812:153560. PMID: 41833075

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (77.67 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H₂O : 50 mg/mL (38.84 mM; Need ultrasonic)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

0.7767 mL

3.8837 mL

7.7674 mL

5 mM

0.1553 mL

0.7767 mL

1.5535 mL

10 mM

0.0777 mL

0.3884 mL

0.7767 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Dilution Calculator

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline

Solubility: ≥ 2.08 mg/mL (1.62 mM); Clear solution

This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)

Solubility: ≥ 2.08 mg/mL (1.62 mM); Clear solution

This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil

Solubility: ≥ 2.08 mg/mL (1.62 mM); Clear solution

This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg
Animal Weight (Per Animal) Animal Weight (Per Animal)
g
Dosing Volume (Per Animal) Dosing Volume (Per Animal)
μL
Number of Animals Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Working solution concentration: 0.22 mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact

MedChemExpress (MCE) .

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (286 KB)
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Itkin M, et al. The biosynthetic pathway of the nonsugar, high-intensity sweetener mogroside V from Siraitia grosvenorii.Proc Natl Acad Sci U S A. 2016 Nov 22;113(47):E7619-E7628.

[2]. Nie J, et al. Mogroside V improves porcine oocyte in vitro maturation and subsequent embryonic development. Theriogenology. 2020 Jan 1;141:35-40. [Content Brief]

[3]. Zhou G, et al. The metabolism of a natural product mogroside V, in healthy and type 2 diabetic rats. J Chromatogr B Analyt Technol Biomed Life Sci. 2018 Mar 15;1079:25-33. [Content Brief]

[4]. Liu C, et al. A natural food sweetener with anti-pancreatic cancer properties. Oncogenesis. 2016 Apr 11;5(4):e217. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
H₂O / DMSO	1 mM	0.7767 mL	3.8837 mL	7.7674 mL	19.4185 mL
	5 mM	0.1553 mL	0.7767 mL	1.5535 mL	3.8837 mL
	10 mM	0.0777 mL	0.3884 mL	0.7767 mL	1.9419 mL
	15 mM	0.0518 mL	0.2589 mL	0.5178 mL	1.2946 mL
	20 mM	0.0388 mL	0.1942 mL	0.3884 mL	0.9709 mL
	25 mM	0.0311 mL	0.1553 mL	0.3107 mL	0.7767 mL
	30 mM	0.0259 mL	0.1295 mL	0.2589 mL	0.6473 mL
DMSO	40 mM	0.0194 mL	0.0971 mL	0.1942 mL	0.4855 mL
	50 mM	0.0155 mL	0.0777 mL	0.1553 mL	0.3884 mL
	60 mM	0.0129 mL	0.0647 mL	0.1295 mL	0.3236 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Mogroside V

Immunology/Inflammation Compound Library

Metabolism/Protease Compound Library

NF-κB Signaling Compound Library

Natural Product Library

Anti-Cancer Compound Library

Anti-Aging Compound Library

Anti-diabetic Compound Library

Glycoside Compound Library

Medicine Food Homology Compound Library

Terpenoids Library

Orally Active Compound Library

Traditional Chinese Medicine Active Compound Library

Anti-Pancreatic Cancer Compound Library

Anti-Cancer Natural Product Library

Anti-inflammatory Traditional Chinese Medicine Active Compound Library

Plant-Sourced Natural Product Library

Heterocyclic Compound Library

Bioactive Compound Library Max

Natural Product Library Plus

Natural Product and Natural Product-Like Compound Library

Bioactive Compound Library

Heat-Clearing and Detoxification Traditional Chinese Medicine Compound Library

High-Throughput Bioactive Compound Library

High-Throughput Natural Product Library

Antitussive and Antiasthmatic Traditional Chinese Medicine Active Compound Library

Diarrhea-Related Traditional Chinese Medicine Active Compound Library

Natural Product Diversity Scaffold Library

Lactylation Compound Library

Mass Spectrometry Natural Product Library

Publications Citing Use of MedChemExpress (MCE) Mogroside V

Biological Activity

Chemical Information

Publications (5)

Solvent & Solubility

Purity & Documentation

References

Help & FAQs

Complete Stock Solution Preparation Table

Mogroside V

Immunology/Inflammation Compound Library

Metabolism/Protease Compound Library

NF-κB Signaling Compound Library

Natural Product Library

Anti-Cancer Compound Library

Anti-Aging Compound Library

Anti-diabetic Compound Library

Glycoside Compound Library

Medicine Food Homology Compound Library

Terpenoids Library

Orally Active Compound Library

Traditional Chinese Medicine Active Compound Library

Anti-Pancreatic Cancer Compound Library

Anti-Cancer Natural Product Library

Anti-inflammatory Traditional Chinese Medicine Active Compound Library

Plant-Sourced Natural Product Library

Heterocyclic Compound Library

Bioactive Compound Library Max

Natural Product Library Plus

Natural Product and Natural Product-Like Compound Library

Bioactive Compound Library

Heat-Clearing and Detoxification Traditional Chinese Medicine Compound Library

High-Throughput Bioactive Compound Library

High-Throughput Natural Product Library

Antitussive and Antiasthmatic Traditional Chinese Medicine Active Compound Library

Diarrhea-Related Traditional Chinese Medicine Active Compound Library

Natural Product Diversity Scaffold Library

Lactylation Compound Library

Mass Spectrometry Natural Product Library

Publications Citing Use of MedChemExpress (MCE) Mogroside V

Biological Activity

Chemical Information

Publications (5)

Solvent & Solubility

Purity & Documentation

References

Help & FAQs

Complete Stock Solution Preparation Table

Mogroside V Related Classifications

HY-N0502 Related Classifications