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Aloxistatin

(Synonyms: E64d; E64c ethyl ester)
90 Cited Publications
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Based on 90 publication(s) in Google Scholar

Aloxistatin (E64d) is a cell-permeable and irreversible broad-spectrum cysteine protease inhibitor. Aloxistatin (E64d) exhibits entry-blocking effect for MERS-CoV.

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  • Pureté: 99.94%
  • CAS No.: 88321-09-9
  • Formule: C17H30N2O5
  • Masse moléculaire:342.43
  • Stockage:
    Powder   -20°C, 3 years , 4°C, 2 years ; In solvent   -80°C, 2 years , -20°C, 1 year
  • Aloxistatin Chemical Structure
    Aloxistatin Chemical Structure
  • Experimental Validation Results for Aloxistatin
  • Experimental Validation Results for Aloxistatin
  • Experimental Validation Results for Aloxistatin
  • Experimental Validation Results for Aloxistatin
  • Experimental Validation Results for Aloxistatin
  • Experimental Validation Results for Aloxistatin
CAS No.: 88321-09-9
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  • Aloxistatin Chemical Structure
    Aloxistatin Chemical Structure
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    Aloxistatin purchased from MedChemExpress. Usage Cited in: Nat Microbiol. 2024 Sep;9(9):2383-2394. [Abstract]

    Customer Validation
     Vero-E6 cells expressing hACE2 and TMPRSS2 were challenged with WT or ΔFCS pseudotyped virus in the presence of aloxistatin at increasing concentrations (0-100 μM). After 48h of infection, cells were lysed, and luciferase expression was quantified. Relative luciferase expression was normalized to untreated cells. The data are presented as the mean percentages of inhibition across six wells. P-values comparing curve fit of WT and ΔFCS viruses are reported.

  • 1/16

    Aloxistatin purchased from MedChemExpress. Usage Cited in: Nat Commun. 2024 Oct 4;15(1):8622. [Abstract]

    Customer Validation
     Elevated Sod1 levels in the medium upon lysosomal dysfunction. Western blots of lysates and media from NSC34 cells treated with Pepstatin A and Aloxistatin (E64d) (10 µg/mL) for 8 h.

  • 1/16

    Aloxistatin purchased from MedChemExpress. Usage Cited in: ACS Nano. 2024 Jul 2;18(26):16790-16807. [Abstract]

    Customer Validation
     TC-1 cells were pretreated with Aloxistatin (E64d) (29 μM)/Pepstatin (14 μM) for 1 h, followed by NP treatment for 24 h. Immunofluorescence results showed that E64d/Pepstatin pretreatment increased the colocalization ratio of FTH1 and NCOA4 in the NP treatment group (n = 3).

  • 1/16

    Aloxistatin purchased from MedChemExpress. Usage Cited in: ACS Nano. 2024 Jul 2;18(26):16790-16807. [Abstract]

    Customer Validation
     TC-1 cells were pretreated with Aloxistatin (E64d) (29 μM)/Pepstatin A (14 μM) for 1 h, followed by NPs treatment for 24 h. Representative immunofluorescence images and co-localization statistics between FTH1 and LAMP2 in normal and NPs-treated TC-1 cells. Immunofluorescence results showed that E64d/Pepstatin A pretreatment increased the co-localization ratio of FTH1 and LAMP2 in NPs treatment group.

  • 1/16

    Aloxistatin purchased from MedChemExpress. Usage Cited in: Signal Transduct Target Ther. 2021 Mar 27;6(1):134. [Abstract]

    Customer Validation
     Analysis of CTSL-mediated S-protein cleavage. Purified SARS-CoV-1 or SARS-CoV-2 S protein was incubated in the presence or absence (assay buffer, pH = 5.5) of CTSL (2 or 10 μg/ml in assay buffer, pH = 5.5) at 37 °C for 1 h. The reaction system of 2 μg/ml CTSL was further supplemented with CTSL inhibitors (20 μM E64d (Aloxistatin) or 20 μM SID 26681509), as indicated. Proteins were subjected to SDS-PAGE and detected by silver staining.

  • 1/16

    Aloxistatin purchased from MedChemExpress. Usage Cited in: Toxicol Appl Pharmacol. 2018 Oct 1;356:159-171. [Abstract]

    Customer Validation
     Western blot analysis of PARP and cleaved PARP levels MIA PaCa-2 and PANC-1 cells pre-treated with inhibitors of lysosomal hydrolases (Aloxistatin, 5 μM) for 1 h, followed by a 24-h treatment with Alan (20 μM).

  • Aloxistatin