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Cat. No.: HY-113071

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Mevalonic acid

(Synonyms: MVA)

12 Cited Publications

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Based on 12 publication(s) in Google Scholar

Mevalonic acid (MVA) is a precursor substance of the mevalonate pathway, which is essential for cell growth and proliferation. Mevalonic acid is effective in inhibiting Simvastatin (HY-17502)-induced decrease in C2C12 cell viability in vitro. Mevalonic acid can be used in studies of myopathy and heart failure.

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CAS No.: 150-97-0
Formule: C₆H₁₂O₄
Masse moléculaire:148.16

Stockage:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month

Mevalonic acid Chemical Structure

CAS No.: 150-97-0

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- In Vitro
Chemical Information
Publications (12)
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
Bioz

Activité biologique

Description

Voir tous les produits spécifiques à Isoform Endogenous Metabolite :

In Vitro

Mevalonic acid (80, 90, 100, 110 μM; 72 h) shows prevention of simvastatin-induced loss of viability of C2C12myotube cells in vitro^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:

C2C12 cells (simvastatin-induced)
Concentration:

80, 90, 100, 110 µM
Incubation Time:

72 h
Result:

Showed no decline in cell viability.

Chemical Information

CAS No. 150-97-0
Appearance Solid
Masse moléculaire 148.16
Formule C₆H₁₂O₄
Color White to off-white
SMILES

O=C(O)CC(C)(O)CCO
Synonyms

MVA
Structure Classification
- Ketones, Aldehydes, Acids
Initial Source
- Endogenous metabolite
- Human Gut Microbiota Metabolites
Livraison

Room temperature in continental US; may vary elsewhere.

Stockage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Publications (12)

All Cell Proliferation/Viability AssayWBBio/Physico-chemical AssayHistological Imaging/StainingIn Vivo Efficacy Study

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Journal Impact Factor

Nature

Lithocholic acid phenocopies anti-ageing effects of calorie restriction. [Abstract]

2025 Jul;643(8070):192-200. PMID: 39695227
Acta Pharm Sin B

Mevalonate improves anti-PD-1/PD-L1 efficacy by stabilizing CD274 mRNA. [Abstract]

2023 Jun;13(6):2585-2600. PMID: 37425040
Acta Pharmacol Sin

Autophagy inhibitors increase the susceptibility of KRAS-mutant human colorectal cancer cells to a combined treatment of 2-deoxy-D-glucose and lovastatin. [Abstract]

2021 Nov;42(11):1875-1887. PMID: 33608672

Mevalonic acid purchased from MedChemExpress. Usage Cited in: Acta Pharmacol Sin. 2021 Nov;42(11):1875-1887. [Abstract]

HCT116 and LoVo cells were cultured with lovastatin (15 μM) and 2DG (5 mM) alone or in combination for 72 h in either the presence or absence of 200 mM Mevalonate, and cell proliferation was determined. *P < 0.05, **P < 0.01. ##P < 0.01 vs corresponding Mevalonic acid lithium salt (MVA) (-) group.
Dev Cell

Tumor-intrinsic FDFT1 determines coordinated macrophage anti-tumor immunity. [Abstract]

2026 Apr 29:S1534-5807(26)00150-4. PMID: 42061405
Cell Biosci

RhoA enhances osteosarcoma resistance to MPPa-PDT via the Hippo/YAP signaling pathway. [Abstract]

2021 Oct 9;11(1):179. PMID: 34627383

Mevalonic acid purchased from MedChemExpress. Usage Cited in: Cell Biosci. 2021 Oct 9;11(1):179. [Abstract]

Western blotting was used to assess changes in the expression of unphosphorylated YAP in HOS and MG63 cells following a 6 h Mevalonic acid lithium salt (Meva) treatment.
Nat Prod Bioprospect

Mevalonic acid exerts procoagulant effect by potentiating factor Xa. [Abstract]

2026 Jan 10;16(1):11. PMID: 41518459

Mevalonic acid purchased from MedChemExpress. Usage Cited in: Nat Prod Bioprospect. 2026 Jan 10;16(1):11. [Abstract]

Mevalonic acid lithium salt (MVA, 500 or 1500 ng/kg; i.v.) significantly shortened activated partial thromboplastin time (APTT) and prothrombin time (PT) in C57BL/C mice.

Mevalonic acid purchased from MedChemExpress. Usage Cited in: Nat Prod Bioprospect. 2026 Jan 10;16(1):11. [Abstract]

Mice were subjected to the inferior vena cava IVC stasis model for 5 h to evaluate venous thrombosis formation, with subsequent pathological assessment by hematoxylin and eosin (HE) staining. The results showed that Mevalonic acid lithium salt (MVA, 500 or 1500 ng/kg; i.v.) treatment markedly increased both thrombus weight.

Mevalonic acid purchased from MedChemExpress. Usage Cited in: Nat Prod Bioprospect. 2026 Jan 10;16(1):11. [Abstract]

Mice were administered injections of either 500 ng/kg Mevalonic acid lithium salt (MVA). On 24 h after transient middle cerebral artery occlusion (tMCAO), typical images of coronal brain sections stained with 2,3,5-triphenyltetrazolium chloride (TTC). The results showed that MVA led to a significant increase in infarct volume.
Biomedicines

c-Myc Sustains Pancreatic Cancer Cell Survival and mutp53 Stability through the Mevalonate Pathway. [Abstract]

2022 Oct 5;10(10):2489. PMID: 36289751
Biochim Biophys Acta Mol Cell Biol Lipids

PCSK9 deficiency results in a specific shedding of excess LDLR in female mice only: Role of hepatic cholesterol. [Abstract]

2022 Dec;1867(12):159217. PMID: 35985474
Integr Cancer Ther

Scutellaria Barbata Water Extract Suppresses Breast Cancer Growth and Lung Metastasis by Inducing Ferroptosis. [Abstract]

2026 Jan-Dec:25:15347354261450966. PMID: 42244109
Life Sci Alliance

Necrotic debris and STING exert therapeutically relevant effects on tumor cholesterol homeostasis. [Abstract]

2022 Jan 4;5(3):e202101256. PMID: 34983824
Drugs R D

Simvastatin Preferentially Targets FLT3/ITD Acute Myeloid Leukemia by Inhibiting MEK/ERK and p38-MAPK Signaling Pathways. [Abstract]

2023 Dec;23(4):439-451. PMID: 37847357
Biochem Biophys Res Commun

Combinatorial screening of a panel of FDA-approved drugs identifies several candidates with anti-Ebola activities. [Abstract]

2020 Feb 19;522(4):862-868. PMID: 31806372

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (268 KB)
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Moschetti A, et al. Coenzyme Q nanodisks counteract the effect of statins on C2C12 myotubes. Nanomedicine. 2021 Oct;37:102439. [Content Brief]

[2]. Soma MR, et al. Cholesterol and mevalonic acid modulation in cell metabolism and multiplication. Toxicol Lett. 1992 Dec;64-65 Spec No:1-15. [Content Brief]

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

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Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

Mevalonic acid

12 Cited Publications

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Activité biologique
- Description
- In Vitro
Chemical Information
Publications (12)
Pureté et documentation
Références

1/16
1/16

Mevalonic acid purchased from MedChemExpress. Usage Cited in: Nat Prod Bioprospect. 2026 Jan 10;16(1):11. [Abstract]

Customer Validation
Mevalonic acid lithium salt (MVA, 500 or 1500 ng/kg; i.v.) significantly shortened activated partial thromboplastin time (APTT) and prothrombin time (PT) in C57BL/C mice.
1/16

Mevalonic acid purchased from MedChemExpress. Usage Cited in: Nat Prod Bioprospect. 2026 Jan 10;16(1):11. [Abstract]

Customer Validation
Mice were subjected to the inferior vena cava IVC stasis model for 5 h to evaluate venous thrombosis formation, with subsequent pathological assessment by hematoxylin and eosin (HE) staining. The results showed that Mevalonic acid lithium salt (MVA, 500 or 1500 ng/kg; i.v.) treatment markedly increased both thrombus weight.
1/16

Mevalonic acid purchased from MedChemExpress. Usage Cited in: Nat Prod Bioprospect. 2026 Jan 10;16(1):11. [Abstract]

Customer Validation
Mice were administered injections of either 500 ng/kg Mevalonic acid lithium salt (MVA). On 24 h after transient middle cerebral artery occlusion (tMCAO), typical images of coronal brain sections stained with 2,3,5-triphenyltetrazolium chloride (TTC). The results showed that MVA led to a significant increase in infarct volume.
1/16

Mevalonic acid purchased from MedChemExpress. Usage Cited in: Acta Pharmacol Sin. 2021 Nov;42(11):1875-1887. [Abstract]

Customer Validation
HCT116 and LoVo cells were cultured with lovastatin (15 μM) and 2DG (5 mM) alone or in combination for 72 h in either the presence or absence of 200 mM Mevalonate, and cell proliferation was determined. *P < 0.05, **P < 0.01. ##P < 0.01 vs corresponding Mevalonic acid lithium salt (MVA) (-) group.
1/16

Mevalonic acid purchased from MedChemExpress. Usage Cited in: Cell Biosci. 2021 Oct 9;11(1):179. [Abstract]

Customer Validation
Western blotting was used to assess changes in the expression of unphosphorylated YAP in HOS and MG63 cells following a 6 h Mevalonic acid lithium salt (Meva) treatment.

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Mevalonic acid

Publications Citing Use of MedChemExpress (MCE) Mevalonic acid

Voir tous les produits spécifiques à Isoform Endogenous Metabolite

Activité biologique

Chemical Information

Publications (12)

Pureté et documentation

Références

Calculators

Help & FAQs

Mevalonic acid Related Classifications

HY-113071 Related Classifications