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SC79

334 Cited Publications
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Based on 334 publication(s) in Google Scholar

SC79, a unique specific and BBB permeable Akt activator, activates Akt in the cytosol and inhibits Akt membrane translocation. SC79 specifically binds to the PH domain of Akt.

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  • Pureté: 98.0%
  • CAS No.: 305834-79-1
  • Formule: C17H17ClN2O5
  • Masse moléculaire:364.78
  • Stockage:
    Powder   -20°C, 3 years , 4°C, 2 years

    * The compound is unstable in solutions, freshly prepared is recommended.

  • SC79 Chemical Structure
    SC79 Chemical Structure
  • Experimental Validation Results for SC79
  • Experimental Validation Results for SC79
  • Experimental Validation Results for SC79
  • Experimental Validation Results for SC79
  • Experimental Validation Results for SC79
  • Experimental Validation Results for SC79
  • Experimental Validation Results for SC79
  • Experimental Validation Results for SC79
  • Experimental Validation Results for SC79
  • Experimental Validation Results for SC79
  • Experimental Validation Results for SC79
CAS No.: 305834-79-1
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  • SC79 Chemical Structure
    SC79 Chemical Structure
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  • 1/16

    SC79 purchased from MedChemExpress. Usage Cited in: Environ Pollut. 2023 Apr 15:323:121306. [Abstract]

    Customer Validation
     SC79 induces mitochondria dysfunction and apoptosis in the heart of zebrafish embryos (Fig D and E).

  • 1/16

    SC79 purchased from MedChemExpress. Usage Cited in: Polymers. 2023 Mar 28;15(7):1681. [Abstract]

    Customer Validation
     SC79 (2.5 μM; 4, 6, 24 h) significantly increases the expression of p-AKT and p-AKT/AKT while decreases p-ERK expression and the ratio of p-ERK/ERK ratio in T84 cells.

  • 1/16

    SC79 purchased from MedChemExpress. Usage Cited in: Polymers. 2023 Mar 28;15(7):1681. [Abstract]

    Customer Validation
     Effect of SC79 (1–10 μM) on T84 cell viability in the absence of COS.

  • 1/16

    SC79 purchased from MedChemExpress. Usage Cited in: Toxicology. 2019 May 1:419:32-39. [Abstract]

    Customer Validation
     HaCaT cells are treated with SC79 at 10 μM for 0, 0.5, 1, and 2 h, following arecoline treatment of 48 h. Proteins are extracted and used for Western blotting for phosphorylated and total Akt, mTOR, 4E-BP1, and cyclin D1. Akt, mTOR, 4E-BP1 and GAPDH are used as the internal control for p-Akt, p-mTOR, p-4E-BP1 and cyclin D1, respectively.

  • 1/16

    SC79 purchased from MedChemExpress. Usage Cited in: Mol Med Rep. 2019 May;19(5):4091-4100. [Abstract]

    Customer Validation
     Western blot analysis demonstrating the protein levels of LC3, p62, AKT, p-AKT, mTOR and p-mTOR following treatment with Aβ1-42, 3-MA, SC79 and SC79 + RAPA for 48 h, and the expression of the AKT/mTOR signaling pathway‑associated proteins of AKT, p-AKT, mTOR and p-mTOR following treatment with Aβ1-42, 3-MA, SC79 and SC79 + RAPA for 48 h.

  • 1/16

    SC79 purchased from MedChemExpress. Usage Cited in: Oncol Rep. 2019 Feb;41(2):811-818. [Abstract]

    Customer Validation
     Cells are cultured with and without CAR/SC79 for 24 h, and cell lysates are prepared and analyzed by western blotting to detect the levels of MDM2 and p53Ser15.

  • 1/16

    SC79 purchased from MedChemExpress. Usage Cited in: Acta Biomater. 2018 Nov:81:278-292. [Abstract]

    Customer Validation
     PC12 cells are pretreated with 740-YP (30 μM), or SC79 (13.7 μM), or 3BDO (100 μM) for 1 h, and for the duration of GO (50 μg/mL) incubation for 24 h. LC3 turnover is detected by western blotting.

  • 1/16

    SC79 purchased from MedChemExpress. Usage Cited in: Nutrients. 2018 Sep 23;10(10):1366. [Abstract]

    Customer Validation
     Competition tests of SC79, PHT-427, AT7867, and AKT inhibitor VIII with the CGA probe against enriched AKT by CGA-modified functionalized MMs. Bands of AKT are detected by Western blot.

  • 1/16

    SC79 purchased from MedChemExpress. Usage Cited in: Biomed Pharmacother. 2018 Oct:106:755-762. [Abstract]

    Customer Validation
     LTEP-a-2 cells are exposed to SC79 and GSK3β and AKT phosphorylation levels are significantly increased.

  • 1/16

    SC79 purchased from MedChemExpress. Usage Cited in: RSC Adv. 2017 Aug 11.

    Customer Validation
     Phillygenin (Phi) modulates phosphorylation of Akt in BEAS-2B cells. BEAS-2B cells are serum-starved overnight and then treated with SC79 and different doses of Phi for 4 h. Thr 308 and Ser 473 phosphorylation of Akt and total Akt are detected by western blot. β-Actin is used as an internal control.

  • 1/16

    SC79 purchased from MedChemExpress. Usage Cited in: Toxicology. 2017 Jul 1:386:72-83. [Abstract]

    Customer Validation
     Western blot assays and quantitative analysis show that BPDE treatment reduces the expression levels of AKT and eNOS; while simultaneous addition of SC79 significantly increases their expression.

  • SC79