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TBHQ

(Synonyms: tert-Butylhydroquinone)
123 Cited Publications
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Based on 123 publication(s) in Google Scholar

TBHQ (tert-Butylhydroquinone) is a widely used Nrf2 activator, protects against Doxorubicin (DOX)-induced cardiotoxicity through activation of Nrf2. TBHQ (tert-Butylhydroquinone) is also an ERK activator; rescues Dehydrocorydaline (DHC)-induced cell proliferation inhibitionin melanoma.

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  • Pureté: 99.86%
  • CAS No.: 1948-33-0
  • Formule: C10H14O2
  • Masse moléculaire:166.22
  • Stockage:

    Store at room temperature 3 years.

    In solvent   -80°C, 2 years , -20°C, 1 year
  • TBHQ Chemical Structure
    TBHQ Chemical Structure
  • Experimental Validation Results for TBHQ
  • Experimental Validation Results for TBHQ
  • Experimental Validation Results for TBHQ
  • Experimental Validation Results for TBHQ
  • Experimental Validation Results for TBHQ
  • Experimental Validation Results for TBHQ
  • Experimental Validation Results for TBHQ
CAS No.: 1948-33-0
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  • TBHQ Chemical Structure
    TBHQ Chemical Structure
    1/16
  • 1/16

    TBHQ purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2025 May 23:e04372. [Abstract]

    Customer Validation
     Protein levels of NRF, PIP5K1A and NQO1 in Hep3B cells treated with tBHQ (TBHQ; 50 μm) or SFN (5 μm) for 24h.

  • 1/16

    TBHQ purchased from MedChemExpress. Usage Cited in: Autophagy. 2025 Feb;21(2):407-423. [Abstract]

    Customer Validation
     RT-PCR to measure expression of NFE2L2 targets in A549 cells infected with WT or ΔS legionella for 6 h in presence of 10 µm tBHQ or ML385.

  • 1/16

    TBHQ purchased from MedChemExpress. Usage Cited in: Nat Commun. 2023 May 13;14(1):2756. [Abstract]

    Customer Validation
     TBHQ (20 μM; 24 h) activates ERK and modestly increases p-EphA2 (Ser897) levels in HL-7702 cells. However, when combined with regorafenib, TBHQ fails to rescue the inhibition of p-EphA2. Under TBHQ treatment, regorafenib still inhibits EphA2 phosphorylation and reduces p-ERK levels.

  • 1/16

    TBHQ purchased from MedChemExpress. Usage Cited in: Nat Commun. 2023 Apr 10;14(1):2004. [Abstract]

    Customer Validation
     TBHQ (1 μM) further promotes TNC (0.5 μg/mL)-induced neurite anomalous bifurcation.

  • 1/16

    TBHQ purchased from MedChemExpress. Usage Cited in: J Nanobiotechnology. 2022 Jun 11;20(1):270. [Abstract]

    Customer Validation
     Immunoblotting analysis and quantification of NRF2 half-life in CuONPs-treated WT or ATG5-KO HUVECs cells. Cells were treated with TBHQ (tBHQ; 10 μM) and CuONPs (20 μg/ml) for 9 h, and then treated with CHX (50 μg/ml) for 0, 1, 2, 3, 6, 9 h, respectively. β-Actin served as loading control.

  • 1/16

    TBHQ purchased from MedChemExpress. Usage Cited in: Front Pharmacol. 2018 Jun 6:9:540. [Abstract]

    Customer Validation
     BHQ promotes higher protein expression of Nrf2 in a time-dependent manner in neonatal rat cardiac fibroblasts (NRCF) while notably downregulated collagen I and collagen III.

  • 1/16

    TBHQ purchased from MedChemExpress. Usage Cited in: Biochem Biophys Res Commun. 2018 Jun 7;500(3):790-796. [Abstract]

    Customer Validation
     Macrophages are isolated from wild-type mice, treated with tBHQ (100 μM) or not, and induced for 3 h using LPS, IFN-g, IL-4 or IL-13. Western blot analysis of the expression of Nrf2, p65 subunit of NF-kB, phosphorylated p65 and PPARg in the cytoplasm and nucleus.

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