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Cat. No.: HY-N21832

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Aplysinol

Aplysinol is an orally effective TLR4 signaling pathway inhibitor. Aplysinol reduces the expression of CD14, MyD88, and NF-κB p65, and downregulates the expression and secretion of TNF-α protein as well as the secretion of IL-1β. Aplysinol restores the phagocytic activity of Kupffer cells and reduces plasma endotoxin levels. Aplysinol alleviates alcohol-induced liver histopathological changes and inhibits the elevation of liver injury biomarkers, and can be used for research related to alcoholic liver disease.

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CAS No.: 6790-64-3
Formule: C₁₅H₁₉BrO₂
Masse moléculaire:311.22

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Aplysinol Chemical Structure

CAS No.: 6790-64-3

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- IC₅₀ & Target
- Cellular Effect
- In Vitro
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
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Activité biologique

Description

IC₅₀ & Target

^[1]

TLR4

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Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	10 μg/mL Compound: 9	Cytotoxicity against human A549 cells by MTT assay Cytotoxicity against human A549 cells by MTT assay	[PMID: 15974618]
Bel-7402	IC₅₀	10 μg/mL Compound: 9	Cytotoxicity against human Bel7402 cells by MTT assay Cytotoxicity against human Bel7402 cells by MTT assay	[PMID: 15974618]
BGC-823	IC₅₀	10 μg/mL Compound: 9	Cytotoxicity against human BGC823 cells by MTT assay Cytotoxicity against human BGC823 cells by MTT assay	[PMID: 15974618]
HCT-8	IC₅₀	10 μg/mL Compound: 9	Cytotoxicity against human HCT8 cells by MTT assay Cytotoxicity against human HCT8 cells by MTT assay	[PMID: 15974618]
HeLa	IC₅₀	10 μg/mL Compound: 9	Cytotoxicity against human HeLa cells by MTT assay Cytotoxicity against human HeLa cells by MTT assay	[PMID: 15974618]

In Vitro

Aplysinol can be isolated from the dietary-derived metabolites of the red alga Laurencia okamurai^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

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Chemical Information

CAS No. 6790-64-3
Masse moléculaire 311.22
Formule C₁₅H₁₉BrO₂
SMILES

C(O)[C@]12[C@](C)(C=3C(O1)=CC(C)=C(Br)C3)CC[C@@H]2C
Structure Classification
- Others
Initial Source
- Marine natural products
- Marine algae
the Red Alga Laurencia tristicha
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Instruction de manipulation (2659 KB)

Références

[1]. Chang Z, et al. Protective effect and underlying mechanism of aplysin on ethanol-induced liver injury in Rats[J]. Food Science, 2020, 41(7): 131-139.

[2]. Palaniveloo K, et al. Halogenated metabolites from the diet of Aplysia dactylomela Rang[J]. Molecules, 2020, 25(4): 815.

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Activité biologique
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Pureté et documentation
Références

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Aplysinol

Voir tous les produits spécifiques à Isoform Toll-like Receptor (TLR)

Voir tous les produits spécifiques à Isoform NF-κB