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Canakinumab

(Synonyms: Ilaris; ACZ 885)
1 Cited Publications
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Based on 1 publication(s) in Google Scholar

Canakinumab (ACZ885) is a recombinant human anti-IL-1β monoclonal antibody. Canakinumab shows IC50 values of 43.6 and 40.8 pM for human and marmoset IL-1β, respectively. The mode of action of canakinumab is based on the neutralization of IL-1β signaling, resulting in suppression of inflammation related to disorders of autoimmune origin.

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  • Pureté: 98.84%
  • CAS No.: 914613-48-2
  • Masse moléculaire:145.5 kDa
  • Stockage:

    Please store the product under the recommended conditions in the Certificate of Analysis.

  • Experimental Validation Results for Canakinumab
  • Experimental Validation Results for Canakinumab
  • Experimental Validation Results for Canakinumab
  • Canakinumab Chemical Structure
    Canakinumab Chemical Structure
CAS No.: 914613-48-2
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Assay Types
  • 1/16

    Human IgG1 kappa

  • 1/16

    Immobilized IL-1 beta Protein, Human (HY-P7028) can bind Canakinumab. The EC50 for this effect is 6.151 ng/mL.

  • 1/16

    Flow cytometric analysis of 1.5X106 RAW264.7 cells treated with 50 nM phorbol-12-myristate-13-acetate (PMA, HY-18739) and 5 μg/ml lipopolysaccharide (LPS, HY-D1056) for 24 hours with Canakinumab (HY-108810, red). Cells were fixed with 4% paraformaldehyde. Then stained with the primary antibody at 1/200 dilution for an hour at 4℃. Goat Anti-Human IgG H&L (AF488) (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃, Human IgG1 kappa, Isotype Control (HY-P99001, blue) was used as the isotype control.

  • Canakinumab Chemical Structure
    1/16
  • Canakinumab
  • Immobilized IL-1 beta Protein, Human (HY-P7028) can bind Canakinumab. The EC50 for this effect is 6.151 ng/mL.
  • Flow cytometric analysis of 1.5X106 RAW264.7 cells treated with 50 nM phorbol-12-myristate-13-acetate (PMA, HY-18739) and 5 μg/ml lipopolysaccharide (LPS, HY-D1056) for 24 hours with Canakinumab (HY-108810, red). Cells were fixed with 4% paraformaldehyde. Then stained with the primary antibody at 1/200 dilution for an hour at 4℃. Goat Anti-Human IgG H&L (AF488) (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃, Human IgG1 kappa, Isotype Control (HY-P99001, blue) was used as the isotype control.