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Cat. No.: HY-178144

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FPR2 agonist 5

FPR2 agonist 5 is a selective Formyl Peptide Receptor 2 (FPR2) agonist. FPR2 agonist 5 induces Ca²⁺ mobilization in FPR2-HL60 transfected cells with an EC₅₀ of 1.2 μM and causes FPR2 desensitization with an IC₅₀ of 0.32 μM. FPR2 agonist 5 exerts neuroprotective effects by mitigating LDH release, NO production, IL-1β, IL-6, IL-33, and IL-10 levels in LPS (HY-D1056)-induced mouse primary microglial cells. FPR2 agonist 5 can be used for the study of neuroinflammatory-related diseases.

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Formule: C₂₆H₂₀FN₅O₂
Masse moléculaire:453.47

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (277 KB)

FPR2 agonist 5 Chemical Structure

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- In Vitro
Chemical Information
Pureté et documentation
Références
Calculators
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Activité biologique

Description

Voir tous les produits spécifiques à Isoform Calcium Channel :

Voir tous les produits spécifiques à Isoform Interleukin Related :

Voir tous les produits spécifiques à Isoform NO Synthase :

In Vitro

FPR2 agonist 5 (Compound (S)-9a) (1 μM, 1 h pretreatment) mitigates LDH release and NO production in LPS-induced mouse primary microglial cells^[1].
FPR2 agonist 5 (1 μM, 1 h pretreatment) decreases LPS-induced increases in IL-1β, IL-6, IL-33, and IL-10 levels in mouse primary microglial cells^[1].
FPR2 agonist 5 induces Ca²⁺ mobilization with an EC₅₀ of 1.2 μM and causes FPR2 desensitization with an IC₅₀ of 0.32 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

ELISA Assay^[1]

Cell Line:

Mouse primary microglial cells
Concentration:

1 μM
Incubation Time:

1 h pretreatment
Result:

Decreased LPS-induced increases in IL-1β, IL-6, IL-33, and IL-10 levels in mouse primary microglial cells.

Chemical Information

Masse moléculaire 453.47
Formule C₂₆H₂₀FN₅O₂
SMILES

N#CC1=CC=C(C[C@H](NC2=NN=C(C3=CC=C(F)C=C3)O2)C(N4CCC5=C4C=CC=C5)=O)C=C1
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (277 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Francavilla F, et al. Design, Synthesis, and Biological Evaluation of Novel Heteroaryl, Squaramide, and Indolcarboxamide Derivatives as Formyl Peptide Receptor 2 Agonists to Target Neuroinflammation. ACS Chem Neurosci. 2025 Sep 3;16(17):3292-3311. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Activité biologique
- Description
- In Vitro
Chemical Information
Pureté et documentation
Références

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FPR2 agonist 5

Voir tous les produits spécifiques à Isoform Calcium Channel

Voir tous les produits spécifiques à Isoform Interleukin Related

Voir tous les produits spécifiques à Isoform NO Synthase