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Cat. No.: HY-189472

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KB02

KB02 is a DCAF16-recruiting ligand that covalently binds to a ligandable cysteine on DCAF16, recruiting the E3 ligase to mediate target protein degradation. KB02 serves as a DCAF16-binding fragment for the synthesis of SHP2 PROTACs.

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CAS No.: 62265-73-0
Formule: C₁₁H₁₂ClNO₂
Masse moléculaire:225.67

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Please store the product under the recommended conditions in the Certificate of Analysis.

KB02 Chemical Structure

CAS No.: 62265-73-0

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

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- In Vitro
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Description

IC₅₀ & Target

DCAF16

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In Vitro

KB02 (7.5 μM; 24 h) alone does not induce SHP2 degradation in HeLa cells but competes with SK8 for DCAF16 binding, thereby inhibiting SK8-induced SHP2 degradation^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[1]

Cell Line:

HeLa
Concentration:

7.5 μM
Incubation Time:

24 h
Result:

Lacked the capability to induce SHP2 degradation.
Significantly inhibited SK8-induced SHP2 degradation.\nDid not induce SHP2 degradation.
Significantly inhibited SK8-induced SHP2 degradation.

Chemical Information

CAS No. 62265-73-0
Masse moléculaire 225.67
Formule C₁₁H₁₂ClNO₂
SMILES

OC1=CC=C(N(C(CCl)=O)CCC2)C2=C1
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Instruction de manipulation (2659 KB)

Références

[1]. Pang X, et al. Discovery of DCAF16-based PROTACs as SHP2 degraders. Bioorganic chemistry. 2026 Oct 05;181:110372.

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Calculateur de dilution

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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KB02

Voir tous les produits spécifiques à Isoform Ligands for E3 Ligase

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IC50 & Target

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Chemical Information

Pureté et documentation

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KB02 Related Classifications

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