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Cat. No.: HY-172732

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PRMT5-IN-50

PRMT5-IN-50 is an orally active and selective inhibitor of PRMT5. PRMT5-IN-50 has good metabolic stability and low clearance rate in human liver microsomes. PRMT5-IN-50 inhibits SDMA/HCT116-MTAPdel and SDMA/HCT116-MTAPwt with IC₅₀s value of 1.0, 536 nM for arginine symmetric methylation, 19, 1620 nM for anti-proliferation, respectively. PRMT5-IN-50 inhibits tumor growth in mice.

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CAS No.: 3002409-47-1
Formule: C₂₆H₂₃F₃N₆O
Masse moléculaire:492.50

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Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (269 KB)

PRMT5-IN-50 Chemical Structure

CAS No.: 3002409-47-1

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique

Description

Voir tous les produits spécifiques à Isoform Histone Methyltransferase :

Chemical Information

CAS No. 3002409-47-1
Masse moléculaire 492.50
Formule C₂₆H₂₃F₃N₆O
SMILES

C[C@@H](N(C(C1=CC=C2N=C(C(C3CC3)=CC2=C1)N)=O)CC4=CC=C(C=N4)C(F)(F)F)C5=NC=CC=N5
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

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Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (269 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Liu B, et al. Prmt5-mta inhibitor. WO2023207556A1.

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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PRMT5-IN-50

Voir tous les produits spécifiques à Isoform Histone Methyltransferase

Activité biologique

Chemical Information

Pureté et documentation

Références

Calculators

Help & FAQs

PRMT5-IN-50 Related Classifications

HY-172732 Related Classifications