STAT3-IN-3
Based on 8 publication(s) in Google Scholar
STAT3-IN-3 is a potent and selective inhibitor of signal transducer and activator of transcription 3 (STAT3), with anti-proliferative activity. STAT3-IN-3 induces apoptosis in breast cancer cells. STAT3-IN-3 acts as a promising mitochondria-targeting STAT3 inhibitor for cancer research.
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- Pureté : 98.40%
- CAS No.: 2361304-26-7
- Formule: C27H26BrN3O6S
- Masse moléculaire:600.48
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Stockage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
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Solvant et solubilité
- Protocole
- Pureté et documentation
- Références
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) STAT3-IN-3
More- Cell Rep Med. 2024 Mar 19;5(3):101472. [Abstract]
- Phytomedicine. 2024 Dec:135:156022. [Abstract]
- Int Immunopharmacol. 2026 Oct 1:186:117075.
- Sci Rep. 2024 Sep 5;14(1):20794. [Abstract]
- J Cell Mol Med. 2026 Feb;30(3):e71050. [Abstract]
- Biochem Biophys Res Commun. 2021 Mar 5:543:29-37. [Abstract]
- Research Square Preprint. 2021 Sep.
- Research Square Preprint. 2021 Apr.
Activité biologique
Description
IC50 & Target
[1]|
STAT3 |
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HCT-116 | IC50 |
1.89 μM
Compound: 7a
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Antiproliferative activity against human HCT116 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
Antiproliferative activity against human HCT116 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
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[PMID: 31048139] |
| HepG2 | IC50 |
2.88 μM
Compound: 7a
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Antiproliferative activity against human HepG2 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
Antiproliferative activity against human HepG2 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
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[PMID: 31048139] |
| L02 | IC50 |
35.6 μM
Compound: 7a
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Cytotoxicity against human LO2 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
Cytotoxicity against human LO2 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
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[PMID: 31048139] |
| MCF-10A | IC50 |
14.62 μM
Compound: 7a
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Cytotoxicity against human MCF10A cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
Cytotoxicity against human MCF10A cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
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[PMID: 31048139] |
| MCF7 | IC50 |
3.33 μM
Compound: 7a
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Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
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[PMID: 31048139] |
| MDA-MB-231 | IC50 |
1.43 μM
Compound: 7a
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Antiproliferative activity against human MDA-MB-231 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
Antiproliferative activity against human MDA-MB-231 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
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[PMID: 31048139] |
In Vitro
STAT3-IN-3 has no influence on the phosphorylation levels of STAT1, JAK2, Src and Erk1/2[1].
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STAT3-IN-3 inhibits the growth of MDA-MB-231, HCT-116, HepG2, and MCF-7 cells with IC50s of 1.43 μM, 1.89 μM, 2.88 μM, and 3.33 μM, respectively[1].
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STAT3-IN-3 down-regulates the expression of STAT3 target genes Bcl-2 and Cyclin D1[1].
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STAT3-IN-3 inhibits STAT3 tyrosine phosphorylation and serine phosphorylation[1].
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STAT3-IN-3 inhibits STAT3 DNA-binding activity[1].
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STAT3-IN-3 (1-4 μM; 24 hours) increases ROS production and remarkably reduces the mitochondrial membrane potential to induce mitochondrial apoptotic pathway[1].
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STAT3-IN-3 (1-4 μM; 24 hours) can induce the cleavage of caspase-9, caspase-3 and PARP[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:MDA-MB-231 cells, HCT-116 cells, HepG2 cells, MCF-7cells
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Concentration:MTT assay
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Incubation Time:48 hours
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Result:Exhibited anti-proliferative activity.
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Cell Line:MDA-MB-231 cells
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Concentration:0 μM, 1 μM, 2 μM, 4 μM
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Incubation Time:24 hours
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Result:Induced the apoptosis of MDA-MB-231 cells dose-dependently and the apoptosis rates.
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Cell Line:MDA-MB-231 cells
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Concentration:0 μM, 1 μM, 2 μM, 4 μM
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Incubation Time:24 hours
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Result:Induced the cleavage of caspase-9, caspase-3 and PARP.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Adult female BALB/c mice (6 weeks of age)[1]
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Dosage:10 mg/kg, 20 mg/kg
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Administration:Intraperitoneal injection, daily, for 14 days
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Result:Significantly inhibited tumor volume.
Chemical Information
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CAS No. 2361304-26-7
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Appearance Solid
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Masse moléculaire 600.48
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Formule C27H26BrN3O6S
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Color Light yellow to yellow
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SMILES
BrC1=C2C(S(C(C(N3CCN(C(C4=CC5=CC=C(N(CC)CC)C=C5OC4=O)=O)CC3)=O)=C2)(=O)=O)=CC=C1
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year
Publications (8)
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Journal Impact Factor
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Most Recent
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Cell Rep Med
STAT3 couples activated tyrosine kinase signaling to the oncogenic core transcriptional regulatory circuitry of anaplastic large cell lymphoma. [Abstract]2024 Mar 19;5(3):101472. PMID: 38508140 -
Phytomedicine
Hypocrellin A against intrahepatic Cholangiocarcinoma via multi-target inhibition of the PI3K-AKT-mTOR, MAPK, and STAT3 signaling pathways. [Abstract]2024 Dec:135:156022. PMID: 39284270 -
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Sci Rep
Downregulation of CIAPIN1 regulates the proliferation, migration and glycolysis of breast cancer cells via inhibition of STAT3 pathway. [Abstract]2024 Sep 5;14(1):20794. PMID: 39242716 -
J Cell Mol Med
Exosomal HMGB1 Orchestrates NSCLC Progression and Immunosuppressive Macrophage Polarisation Through the TLR4/NF-κB/IL-6/STAT3 Signalling Cascade. [Abstract]2026 Feb;30(3):e71050. PMID: 41645802 -
Biochem Biophys Res Commun
Suppression of PAPP-A mitigates atherosclerosis by mediating macrophage polarization via STAT3 signaling. [Abstract]2021 Mar 5:543:29-37. PMID: 33508770 -
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Solvant et solubilité
In Vitro:
DMSO : 5 mg/mL (8.33 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureté et documentation
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Fiche technique (277 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Instruction de manipulation (2659 KB)
Références
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.6653 mL | 8.3267 mL | 16.6533 mL | 41.6334 mL |
| 5 mM | 0.3331 mL | 1.6653 mL | 3.3307 mL | 8.3267 mL |
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