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Cat. No.: HY-106928

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U 93385

U93385 is a 5-HT₁A receptor agonist. U93385 exhibits no significant α₂ adrenergic, D₂ dopamine, or other receptor activities. U93385 has a heart rate regulating effect, stimulating the vagus nerve to induce bradycardia. U93385 can be used to study the 5-HT₁A receptor-mediated vagal nerve tolerance mechanism.

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CAS No.: 147145-16-2
Formule: C₁₆H₂₂N₂O
Masse moléculaire:258.36

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (270 KB)

U 93385 Chemical Structure

CAS No.: 147145-16-2

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- IC₅₀ & Target
- In Vivo
Chemical Information
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Description

IC₅₀ & Target^[2]

5-HT_1A Receptor

Voir tous les produits spécifiques à Isoform 5-HT Receptor :

In Vivo

U 93385 (0.01-3 mg/kg, i.v., single dose, cumulative administration or intravenous infusion) results in a 20-30% decrease in heart at administration of a single dose but fails to lower heart rate in the spinal cat by cumulative dosing and infusion^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Spinal cord transection model established in cats (2.5-4 kg)^[1]
Dosage:

0.3, 1.0, 3.0 mg/kg (single dose); 0.01, 0.03, 0.1, 0.3, 1.0, 3.0 mg/kg (cumulative dose); 1 mg/kg (infusion)
Administration:

Intravenous injection (i.v.), single dose, cumulative administration or intravenous infusion
Result:

Dose-dependently reduced bradycardia and arterial blood pressure at single dose.
Failed to lower heart rate in animals pretreated in this cumulative manner.

Chemical Information

CAS No. 147145-16-2
Masse moléculaire 258.36
Formule C₁₆H₂₂N₂O
SMILES

NC(C1=C2[C@@]3([H])[C@](CCC2=CC=C1)([H])N(CCC)CC3)=O
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (270 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. McCall RB, et al. Rapid and long duration tolerance to the vagal bradycardic effects of 5-HT1A receptor agonists. Behav Brain Res. 1996;73(1-2):297-300. [Content Brief]

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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- In Vivo
Chemical Information
Pureté et documentation
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U 93385

Voir tous les produits spécifiques à Isoform 5-HT Receptor

Activité biologique

Chemical Information

Pureté et documentation

Références

Calculators

Help & FAQs

U 93385 Related Classifications

HY-106928 Related Classifications