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Cat. No.: HY-119765

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VU0366248

VU0366248 is a mGlu5 negative allosteric modulator.

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CAS No.: 1243310-20-4
Formule: C₁₄H₇ClF₂N₂O
Masse moléculaire:292.67

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (266 KB)

VU0366248 Chemical Structure

CAS No.: 1243310-20-4

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- IC₅₀ & Target
- Cellular Effect
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
Bioz

Activité biologique

Description

VU0366248 is a mGlu5 negative allosteric modulator^[1].

IC₅₀ & Target

mGluR5

Voir tous les produits spécifiques à Isoform mGluR :

Cellular Effect

Cell Line	Type	Value	Description	References
HEK293-A	IC₅₀	347 nM Compound: 41	Antagonist activity at rat mGlu5 receptor expressed in HEK293A cells assessed as inhibition of glutamate-induced calcium mobilization Antagonist activity at rat mGlu5 receptor expressed in HEK293A cells assessed as inhibition of glutamate-induced calcium mobilization	[PMID: 20598884]

Chemical Information

CAS No. 1243310-20-4
Masse moléculaire 292.67
Formule C₁₄H₇ClF₂N₂O
SMILES

O=C(C1=CC(F)=CC(C#N)=C1)NC2=CC=CC(Cl)=C2F
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (266 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Karen J Gregory, et al. Investigating Metabotropic Glutamate Receptor 5 Allosteric Modulator Cooperativity, Affinity, and Agonism: Enriching Structure-Function Studies and Structure-Activity Relationships. Mol Pharmacol. 2012 Nov;82(5):860-75. [Content Brief]

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Molecular Weight Molecular Weight

Calculateur de dilution

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Activité biologique
- Description
- IC₅₀ & Target
Chemical Information
Pureté et documentation
Références

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VU0366248

Voir tous les produits spécifiques à Isoform mGluR

Activité biologique

Chemical Information

Pureté et documentation

Références

Calculators

Help & FAQs

VU0366248 Related Classifications

HY-119765 Related Classifications