- Recombinant Proteins
- CD Antigens Fc Receptors
- Macrophage CD Proteins Monocyte CD Proteins Platelet CD Proteins Dendritic Cell CD Proteins Fc-gamma Receptor
- Fc gamma RII/CD32
- FCGR2A/CD32a
FCGR2A/CD32a
FCGR2A (CD32a) is the broadly expressed, activating member of the FcγRII/CD32 family. It is a low-affinity receptor for the Fc region of IgG, found on monocytes, macrophages, dendritic cells, neutrophils, eosinophils and platelets. CD32a signals through an intrinsic ITAM in its cytoplasmic tail, recruiting SYK to trigger phagocytosis of immune complexes, antibody-dependent cellular cytotoxicity, cytokine release and inflammatory responses. A common H131R polymorphism alters binding to human IgG2 and influences susceptibility to infections and autoimmune diseases. On platelets, CD32a mediates heparin-induced thrombocytopenia triggered by anti-PF4/heparin antibodies. CD32a engagement is also a key design consideration for therapeutic antibodies that rely on myeloid effector functions.
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FCGR2A/CD32a Recombinant Proteins (15)
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- 1
Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- 1
- Formel: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
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