Nithiazide
Nithiazide is an anti-histomonad agent with activity against Histomonas. Nithiazide does not cause macroscopic or histopathological abnormalities in the visceral organs of turkeys and chickens at specified doses and durations. Nithiazide induces tumor formation in multiple organs of rodents. Nithiazide can be used in research related to enterohepatitis and tumors, such as breast tumors, skin fibroadenomas, cystadenomas, liver tumors, etc.
For research use only. We do not sell to patients.
- CAS No.: 139-94-6
- Formula: C6H8N4O3S
- Molecular Weight:216.22
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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- References
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Biological Activity
Nithiazide exhibits genotoxic activity, testing positive in both the Ames Salmonella mutagenesis assay and the Chinese hamster ovary cell chromosomal abnormality assay[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Nithiazide (added to feed at 0.05-0.2%; administered via ad libitum oral feeding for 21 days) exerts no significant adverse effects on the growth of turkeys[1].
Nithiazide (added to feed at a ratio of 0.0062-0.4% and administered via ad libitum oral feeding for 21 days) has a safe feeding window (≤0.05%); dose-dependent growth inhibition occurs beyond this threshold, but no lethal toxicity is observed[1].
Nithiazide (added to feed at a proportion of 0.0125-0.1%, administered via ad libitum oral feeding for 11-27 weeks) exerts no effect on the growth or feed conversion rate of turkeys at a treatment-related dietary level (≤0.1%) with long-term feeding[1].
Nithiazide (added to feed at concentrations of 0.0125-0.1%; administered orally; ad libitum feeding; continuous dosing until egg laying ceases at 62-63 weeks) at standard therapeutic doses does not impair the reproductive performance of turkeys, and only the highest tested concentration slightly delays sexual maturity and reduces egg weight[1].
Nithiazide (added to feed at a proportion of 0.05-0.28%, administered via ad libitum oral feeding for 14-19 weeks) has far weaker egg-suppressive toxicity than ANT/ACT; White Leghorn hens are more sensitive to nitrothiazole toxicity[1].
Nithiazide (feed) exhibits in vivo carcinogenic activity in rodents, and induces tumorigenesis in three distinct organs of male and female rats and mice[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:White Rock chicks and Beltsville White turkeys (2-week-old)
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Dosage:400 mg/kg; 800 mg/kg; 1600 mg/kg; 3200 mg/kg; 6400 mg/kg
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Administration:p.o.; single dose
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Result:Zero mortality in chicks and poults for all Nithiazide doses (400–6400 mg/kg).
3200 mg/kg showed no growth retardation; 6400 mg only mild growth suppression (chick 86%, poult 96% of control weight gain).
ANT caused death starting at 400 mg/kg, 100% chick mortality at 800 mg; ACT was far more toxic than Nithiazide.
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Animal Model:2-week-old poults[1]
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Dosage:0.05%; 0.1%; 0.2%
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Administration:p.o.; ad libitum for 21 days
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Result:Showed no effect on chick growth with continuous feeding of 0.0062% to 0.05% nithiazide in feed.
Caused linear dose-response growth retardation with continuous feeding of 0.1% to 0.4% concentrations, with 0.2% reducing growth to ~50% of normal, and 0.4% causing considerable growth retardation with 0% mortality.
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Animal Model:White Rock chicks (3-day-old)[1]
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Dosage:0.0062%; 0.0125%; 0.025%; 0.05%; 0.1%; 0.2%; 0.4%
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Administration:p.o.; ad libitum for 21 days
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Result:Low doses 0.0062%–0.05% showed no difference in chick weight vs control;
Linear growth suppression starting at ≥0.1%; 0.2% reduced body weight to half of control;
No mortality even at maximum 0.4% feed content, only severe stunting.
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Animal Model:Mixed-sex White Holland poults[1]
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Dosage:0.0125%; 0.025%; 0.05%; 0.1%
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Administration:p.o.; ad libitum for 11-27 weeks
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Result:0.0125%–0.1% Nithiazide fed for 11/27 weeks produced no significant negative impacts on turkey weight or feed efficiency.
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Animal Model:27-week mature turkeys[1]
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Dosage:0.0125%; 0.025%; 0.05%; 0.1%
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Administration:p.o.; ad libitum; continuous medication until egg production ceased at 62–63 weeks
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Result:Showed no adverse effects on body weight, egg production, fertility or hatchability at 0.0125%-0.05%.
Slightly delayed sexual maturity and mildly reduced egg weight, fertility unchanged at 0.1%.
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Animal Model:Mature White Leghorn and New Hampshire laying hens[1]
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Dosage:0.05%; 0.1%; 0.14%; 0.2%; 0.28%
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Administration:p.o.; ad libitum for 14-19 weeks
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Result:Fed to White Leghorns for 14 weeks caused no obvious egg production drop at 0.05% & 0.1%.
New Hampshire hens had higher tolerance; 0.1-0.28% Nithiazide for 19 weeks did not interfere with laying.
Chemical Information
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CAS No. 139-94-6
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Molecular Weight 216.22
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Formula C6H8N4O3S
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SMILES
O=C(NC1=NC=C([N+]([O-])=O)S1)NCC
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Nithiazide Related Classifications
HY-W650831 Related Classifications
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