Piperilate
Piperilate (Pipethanate) is one of the mixtures of hetrazepine derivative PAF antagonists with anticholinergics, can be used for bronchial asthma research. Piperilate also causes hypotension and rescues mice poisoned by the organophosphates.
For research use only. We do not sell to patients.
- CAS No.: 4546-39-8
- Formula: C21H25NO3
- Molecular Weight:339.43
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Piperilate (1 mg/kg; i.v.) causes hypotension in rabbit which is not blocked by dichloroisoproterenol or Atropine (HY-B1205)[2].
Piperilate (3 mg/kg; i.v.) decreases respiration and heart rate of test rabbits, blocks the Adrenaline (HY-122304)-induced constriction of an isolated rabbit auricle preparation[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Male albino mice (18-22 g)[1]
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Dosage:11.3 mg/kg, 29.42 mg/kg
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Administration:Intraperitoneal injection; single dose
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Result:Showed anticholinergic activity with EC50 values of 11.33 mg/kg (antagonism of oxotremorine induced salivation) and 29.42 mg/kg (antagonism of oxotremorine induced tremor) in mice.
Chemical Information
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CAS No. 4546-39-8
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Molecular Weight 339.43
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Formula C21H25NO3
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SMILES
O=C(OCCN1CCCCC1)C(C2=CC=CC=C2)(C3=CC=CC=C3)O
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Synonyms
Pipethanate
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Faff J, et al. Therapeutic effects of some cholinolytics in organophosphate intoxications. Arch Toxicol. 1976 Oct 28;36(2):139-46. [Content Brief]
[2]. Tanaka S, et al. [Studies on pharmacological effect of pipethanate. II. Effect of pipethanate on respiration, circulation system and smooth muscle]. Eisei Shikenjo Hokoku. 1971;89:54-8. Japanese. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Piperilate Related Classifications
HY-105790 Related Classifications
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