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Cat. No.: HY-N19794

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Derrisaponin A

Derrisaponin A is an oleanane-type triterpenoid saponin and sweetener found in the stems of Derris eriocarpa, with sweetness intensity approximately 80 times that of Sucrose (HY-B1779) at 1% concentration. Derrisaponin A shows no acute toxic activity. Derrisaponin A can be used for research on hypertension, hyperglycemia, and obesity.

For research use only. We do not sell to patients.

CAS No.: 1965272-21-2
Formula: C₅₆H₈₈O₂₆
Molecular Weight:1177.28

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Derrisaponin A Chemical Structure

CAS No.: 1965272-21-2

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Biological Activity
- Description
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

In Vitro

Derrisaponin A (Compound 2) (2 mg; 2 h) produces D-glucuronic acid (HY-N6612), D-galactose (HY-N0210), L-rhamnose (HY-N1420), and D-glucose (HY-B0389) upon acid hydrolysis^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Derrisaponin A (Compound 2) (400 mg/kg bw; i.v.; single injection) has a maximum tolerated dose of 400 mg/kg bw in ICR mice when administered as a single intravenous injection, with no persistent acute toxic effects observed over 14 days^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

ICR mice (male and female, 3-4 weeks old, specific pathogen-free)^[1]
Dosage:

400 mg/kg bw
Administration:

i.v.; single injection
Result:

Observed transient diaphragm spasm in one mouse that resolved within 10 minutes post-injection.
Detected no other treatment-related clinical signs of toxicity, mortality, or gross pathological changes to internal organs over the 14-day observation period.
Determined the maximum tolerated dose (MTD) to be 400 mg/kg bw.

Chemical Information

CAS No. 1965272-21-2
Molecular Weight 1177.28
Formula C₅₆H₈₈O₂₆
SMILES

C[C@]12[C@]3(C([C@@]4([H])[C@@](CC3)([C@@H](C[C@@](C)(C4)C(O)=O)OC(C)=O)C)=CC[C@]1([H])[C@@]5([C@@]([C@](C)([C@H](CC5)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)C(O)=O)O)O)O[C@H]7[C@@H]([C@H]([C@H]([C@H](O7)CO)O)O[C@@H]8O[C@@H]([C@H]([C@@H]([C@H]8O)O)O)CO)O[C@H]9[C@@H]([C@@H]([C@H]([C@@H](O9)C)O)O)O)CO)([H])CC2)C)C
Structure Classification
- Terpenoids
- Triterpenes
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Zhang HX, et al. New Sweet-Tasting Oleanane-Type Triterpenoid Saponins from "Tugancao" (Derris eriocarpa How). J Agric Food Chem. 2017;65(11):2357-2363. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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