DPP8/9-IN-2
DPP8/9-IN-2 (Compound 21) is a DPP8/9 inhibitor with IC50 values of 0.22 nM and 3 nM, respectively, and Ki values of 2.9 nM and 6 nM, respectively . DPP8/9-IN-2 has certain cardiotoxicity, with IC50 values of 0.7 μM, 29.0 μM and 27.7 μM for hERG potassium channel, Nav1.5 sodium channel and Cav1.2 calcium channel, respectively. DPP8/9-IN-2 can be used in the research of diseases such as tumors.
For research use only. We do not sell to patients.
- CAS No.: 3109603-86-0
- Formula: C30H30F3N3O2
- Molecular Weight:521.57
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
All Calcium Channel Isoforms
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Biological Activity
Description
IC50 & Target
[1]|
DPP-8 0.22 nM (IC50) |
DPP-9 3 nM (IC50) |
Nav1.5 29.0 μM (IC50) |
DPP-8 2.9 nM (Ki) |
DPP-9 6 nM (Ki) |
Chemical Information
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CAS No. 3109603-86-0
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Molecular Weight 521.57
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Formula C30H30F3N3O2
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SMILES
O=C(N1CC2=C(C=C(F)C=C2)C1)[C@@H](N)CC(N3CCC(C(C4=CC=C(F)C=C4)C5=CC=C(F)C=C5)CC3)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocols
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
DPP8/9-IN-2 Related Classifications
HY-175226 Related Classifications
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