Fyn - Fyn proto-oncogene Gene

Species: Mus musculus

Gene Type: protein coding
Gene ID: 14360

Summary

Enables several functions, including cytoskeletal protein binding activity; protein tyrosine kinase activity; and transmembrane transporter binding activity. Involved in several processes, including negative regulation of dendritic spine maintenance; positive regulation of protein targeting to membrane; and positive regulation of tyrosine phosphorylation of STAT protein. Acts upstream of or within several processes, including cellular response to growth factor stimulus; nervous system development; and protein phosphorylation. Located in several cellular components, including Schaffer collateral - CA1 synapse; actin filament; and postsynaptic density. Is expressed in several structures, including alimentary system; central nervous system; cranial nerve; genitourinary system; and sensory organ. Used to study skin disease and skin squamous cell carcinoma. Human ortholog(s) of this gene implicated in Alzheimer's disease and schizophrenia. Orthologous to human Fyn (Fyn proto-oncogene, Src family tyrosine kinase). [provided by Alliance of Genome Resources, Apr 2022]

Fyn Products (3)

mRNA Protein Name
NM_001122892.1 NP_001116364.1 tyrosine-protein kinase Fyn isoform b
NM_001122893.1 NP_001116365.1 tyrosine-protein kinase Fyn isoform a
NM_008054.2 NP_032080.2 tyrosine-protein kinase Fyn isoform b

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables G protein-coupled receptor binding IPI
IPI: Inferred from physical interaction
23169819 MGI
enables alpha-tubulin binding IDA
IDA: Inferred from direct assay
11826099 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
7730365 MGI
enables protein kinase activity IDA
IDA: Inferred from direct assay
11826099 MGI
enables protein tyrosine kinase activity EXP
EXP: Inferred from Experiment
16709819 MGI
enables protein tyrosine kinase activity IDA
IDA: Inferred from direct assay
8175795 MGI
enables protein tyrosine kinase activity IGI
IGI: Inferred from genetic interaction
23169819 MGI
enables tau protein binding IPI
IPI: Inferred from physical interaction
11826099 MGI
enables transmembrane transporter binding IPI
IPI: Inferred from physical interaction
12538589 MGI
enables tubulin binding IDA
IDA: Inferred from direct assay
11826099 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within activated T cell proliferation IMP
IMP: Inferred from mutant phenotype
1516132 MGI
acts upstream of or within cell surface receptor signaling pathway IDA
IDA: Inferred from direct assay
9177270 MGI
acts upstream of or within cellular response to platelet-derived growth factor stimulus IDA
IDA: Inferred from direct assay
17623777 MGI
acts upstream of or within cellular response to transforming growth factor beta stimulus IGI
IGI: Inferred from genetic interaction
21829547 MGI
acts upstream of or within dendrite morphogenesis IMP
IMP: Inferred from mutant phenotype
12372285 MGI
acts upstream of or within detection of mechanical stimulus involved in sensory perception of pain IMP
IMP: Inferred from mutant phenotype
16190898 MGI
acts upstream of or within forebrain development IGI
IGI: Inferred from genetic interaction
16162939 MGI
acts upstream of or within forebrain development IMP
IMP: Inferred from mutant phenotype
15073522 MGI
acts upstream of or within gene expression IGI
IGI: Inferred from genetic interaction
31461442 MGI
involved in heart process IGI
IGI: Inferred from genetic interaction
27525436 MGI
involved in modulation of chemical synaptic transmission IDA
IDA: Inferred from direct assay
1361685 MGI
involved in modulation of chemical synaptic transmission IMP
IMP: Inferred from mutant phenotype
1361685 MGI
involved in negative regulation of angiogenesis IMP
IMP: Inferred from mutant phenotype
10613822 MGI
involved in negative regulation of dendritic spine maintenance IGI
IGI: Inferred from genetic interaction
22820466 MGI
involved in negative regulation of gene expression IMP
IMP: Inferred from mutant phenotype
20978343 MGI
acts upstream of or within negative regulation of protein catabolic process IMP
IMP: Inferred from mutant phenotype
16841086 MGI
acts upstream of or within negative regulation of protein ubiquitination IDA
IDA: Inferred from direct assay
24627473 MGI
acts upstream of or within neuron migration IGI
IGI: Inferred from genetic interaction
16162939 MGI
acts upstream of or within neuron migration IMP
IMP: Inferred from mutant phenotype
15073522 MGI
acts upstream of neuron projection development IGI
IGI: Inferred from genetic interaction
18354028 MGI
acts upstream of or within peptidyl-tyrosine phosphorylation IDA
IDA: Inferred from direct assay
8175795 MGI
involved in peptidyl-tyrosine phosphorylation IDA
IDA: Inferred from direct assay
12681493 MGI
acts upstream of or within peptidyl-tyrosine phosphorylation IMP
IMP: Inferred from mutant phenotype
9381182 MGI
involved in peptidyl-tyrosine phosphorylation IMP
IMP: Inferred from mutant phenotype
27525436 MGI
acts upstream of or within positive regulation of neuron projection development IGI
IGI: Inferred from genetic interaction
18354028 MGI
acts upstream of or within positive regulation of protein localization to nucleus IDA
IDA: Inferred from direct assay
20142099 MGI
involved in positive regulation of protein localization to nucleus IMP
IMP: Inferred from mutant phenotype
20142099 MGI
involved in positive regulation of protein targeting to membrane IGI
IGI: Inferred from genetic interaction
22820466 MGI
involved in positive regulation of tyrosine phosphorylation of STAT protein IMP
IMP: Inferred from mutant phenotype
23438599 MGI
acts upstream of or within protein autophosphorylation IDA
IDA: Inferred from direct assay
8175795 MGI
acts upstream of protein catabolic process IMP
IMP: Inferred from mutant phenotype
16841086 MGI
acts upstream of or within protein phosphorylation IMP
IMP: Inferred from mutant phenotype
9892651 MGI
acts upstream of protein ubiquitination IDA
IDA: Inferred from direct assay
24627473 MGI
involved in reelin-mediated signaling pathway IDA
IDA: Inferred from direct assay
12526739 MGI
involved in regulation of calcium ion import across plasma membrane IGI
IGI: Inferred from genetic interaction
22820466 MGI
acts upstream of or within regulation of cell shape IDA
IDA: Inferred from direct assay
11826099 MGI
involved in regulation of glutamate receptor signaling pathway IGI
IGI: Inferred from genetic interaction
22820466 MGI
involved in regulation of peptidyl-tyrosine phosphorylation IGI
IGI: Inferred from genetic interaction
22820466 MGI
involved in response to amyloid-beta IGI
IGI: Inferred from genetic interaction
22820466 MGI
acts upstream of or within response to ethanol IGI
IGI: Inferred from genetic interaction
9381182 MGI
Cellular Component GO Annotation Evidence References Source
is active in Schaffer collateral - CA1 synapse IDA
IDA: Inferred from direct assay
1361685 MGI
is active in Schaffer collateral - CA1 synapse IMP
IMP: Inferred from mutant phenotype
1361685 MGI
located in actin filament IDA
IDA: Inferred from direct assay
17623777 MGI
located in cell body IDA
IDA: Inferred from direct assay
11826099 MGI
located in cell periphery IDA
IDA: Inferred from direct assay
17623777 MGI
located in dendrite IMP
IMP: Inferred from mutant phenotype
20655099 MGI
located in endosome IDA
IDA: Inferred from direct assay
17623777 MGI
located in glial cell projection IDA
IDA: Inferred from direct assay
11826099 MGI
located in membrane raft IDA
IDA: Inferred from direct assay
11826099 MGI
located in plasma membrane IDA
IDA: Inferred from direct assay
10557075 MGI
located in postsynaptic density IMP
IMP: Inferred from mutant phenotype
20655099 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

tyrosine-protein kinase Fyn

  • Src Kinase p59

  • p59-Fyn

  • proto-oncogene c-Fyn

  • proto-oncogene tyrosine-protein kinase Fyn

Fyn Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
Fyn P39688 Pdgfrb Mus musculus P05622
Pull Down
7730365
Cross
Fyn P39688 CBL Homo sapiens P22681
Pull Down
9890970
Cross
Fyn P39688 CBL Homo sapiens P22681
Far-WB
9890970
Intra
Fyn P39688 Khdrbs1 Mus musculus Q60749
Y2H
15102471
Cross
Fyn P39688 FZD2 Homo sapiens Q14332
Pull Down
25417160
Intra
Fyn P39688 Dynlt1 Mus musculus P51807
Y2H
15102471
Intra
Fyn P39688 Slamf1 Mus musculus Q9QUM4
Anti Bait CoIP
12545173
Intra
Fyn P39688 Slamf1 Mus musculus Q9QUM4
Anti Tag CoIP
12545173
Intra
Fyn P39688 Slamf1 Mus musculus Q9QUM4
Pull Down
16847311
Intra
Fyn P39688 Slamf1 Mus musculus Q9QUM4
Anti Bait CoIP
11477403
Intra
Fyn P39688 Khdrbs2 Mus musculus Q9WU01
Pull Down
10077576
Intra
Fyn P39688 Sphk2 Mus musculus Q9JIA7
Anti Bait CoIP
16316995
Cross
Fyn P39688 Irs1 Rattus norvegicus P35570
Pull Down
8631859
Cross
Fyn P39688 Irs1 Rattus norvegicus P35570
Anti Bait CoIP
8631859
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-157442 GLPG3312 Inhibitor 98.63% Phase 1

Pre-clinical Phase

Bioactive Molecules (7)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-176892A Papaveroline hydrochloride Inhibitor 99.04% Unkown
HY-176892 Papaveroline Inhibitor / Unkown
HY-118105 RK-20448 Inhibitor 99.38% Unkown
HY-180938 Fyn-IN-1 Inhibitor / Unkown
HY-183584 ARN25699 Inhibitor / Unkown
HY-176194 Antifibrotic agent 1 Inhibitor / Unkown
HY-120622 BMS-243117 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Fyn NCBI NCBI:2534