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Xirestomig

(Synonyms: ATG-101)
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Based on 1 Customer Validation

Xirestomig (ATG-101) is a tetravalent "2+2″ PD-L1×4-1BB bispecific antibody. Xirestomig binds PD-L1 and 4-1BB concurrently, with a greater affinity for PD-L1, and potently activated 4-1BB+ T cells when cross-linked with PD-L1-positive cells. Xirestomig activates exhausted T cells upon PD-L1 binding. Xirestomig displays potent antitumor activity in numerous in vivo tumor models, including those resistant or refractory to immune checkpoint inhibitors (ICIs).

For research use only. We do not sell to patients.

  • Purity: 98.44%
  • CAS No.: 2756879-35-1
  • Molecular Weight:196.508 kDa
  • Storage:

    Please store the product under the recommended conditions in the Certificate of Analysis.

  • Experimental Validation Results for Xirestomig
  • Experimental Validation Results for Xirestomig
  • Experimental Validation Results for Xirestomig
  • Xirestomig Chemical Structure
    Xirestomig Chemical Structure
CAS No.: 2756879-35-1
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Tel: 609-228-6898 E-mail: [email protected] [email protected]

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Xirestomig Product Recommendations:

To place orders, for customer services and technical support, please contact:

609-228-6898
[email protected] [email protected]
Find Your Local Distributor Your local distributor: Hycultec GmbHHycultec
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Assay Types
  • 1/16

    IgG1-lambda-[scFv]2-heavy-lambda

  • 1/16

    Immobilized PD-L1 Protein, Human (HEK293, HY-P73361) can bind Xirestomig. The EC50 for this effect is 51.02 ng/mL.

  • 1/16

    Immobilized 4-1BB/TNFRSF9 Protein, Human (HEK293, His, HY-P70678) can bind Xirestomig. The EC50 for this effect is 56.02 ng/mL.

  • Xirestomig Chemical Structure
    1/16
  • Xirestomig
  • Immobilized PD-L1 Protein, Human (HEK293, HY-P73361) can bind Xirestomig. The EC50 for this effect is 51.02 ng/mL.
  • Immobilized 4-1BB/TNFRSF9 Protein, Human (HEK293, His, HY-P70678) can bind Xirestomig. The EC50 for this effect is 56.02 ng/mL.
  • IgG1-lambda-[scFv]2-heavy-lambda