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Cat. No.: HY-103091

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Donitriptan hydrochloride

(Synonyms: F-11356)

Donitriptan hydrochloride (F-11356) is a potent, high efficacy agonist at 5-HT_1B/1D receptors with pK_is of 9.4 and 9.3, respectively.

For research use only. We do not sell to patients.

CAS No.: 170911-68-9
Formula: C₂₃H₂₆ClN₅O₂
Molecular Weight:439.94

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (265 KB)

Donitriptan hydrochloride Chemical Structure

CAS No.: 170911-68-9

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Bioz

Biological Activity

Description

Donitriptan hydrochloride (F-11356) is a potent, high efficacy agonist at 5-HT_1B/1D receptors with pK_is of 9.4 and 9.3, respectively^[1].

IC₅₀ & Target

5-HT_1B Receptor

9.4 (pKi)

5-HT_1D Receptor

9.3 (pKi)

All 5-HT Receptor Isoforms :

Chemical Information

CAS No. 170911-68-9
Molecular Weight 439.94
Formula C₂₃H₂₆ClN₅O₂
SMILES

N#CC1=CC=C(N2CCN(C(COC3=CC4=C(NC=C4CCN)C=C3)=O)CC2)C=C1.[H]Cl
Synonyms

F-11356
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (265 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Muñoz-Islas E, et al. Donitriptan, but not sumatriptan, inhibits capsaicin-induced canine external carotid vasodilatation via 5-HT1B rather than 5-HT1D receptors. Br J Pharmacol. 2006 Sep;149(1):82-91. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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