EP300/CBP ligand 2

Cat. No.: HY-161960: Data Sheet Handling Instructions
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EP300/CBP ligand 2 (compound S19) is a ligand targeting the bromodomain of CREB binding protein (CBP) and E1A-associated protein (EP300). EP300/CBP ligand 2 can be used as a target protein ligand in the PROTAC structure, and can be coupled to the E3 ubiquitin ligase ligand through the PTOTAC Linker to synthesize PROTAC molecules with degradation effects. For example, EP300/CBP ligand 2 can be coupled with the conjugate (E3 ubiquitin enzyme ligand + Linker) Thalidomide-NH-C10-Boc (HY-161961) to produce the PROTAC molecule dCE-2 (HY-161958).

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EP300/CBP ligand 2 화학구조

사이즈		재고
MOQ		Minimum order quantity
50 mg		견적 받기
100 mg		견적 받기
250 mg		견적 받기
Other size		견적 받기

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Biological Activity
순도&문서
References
고객리뷰

제품 설명	EP300/CBP ligand 2 (compound S19) is a ligand targeting the bromodomain of CREB binding protein (CBP) and E1A-associated protein (EP300). EP300/CBP ligand 2 can be used as a target protein ligand in the PROTAC structure, and can be coupled to the E3 ubiquitin ligase ligand through the PTOTAC Linker to synthesize PROTAC molecules with degradation effects. For example, EP300/CBP ligand 2 can be coupled with the conjugate (E3 ubiquitin enzyme ligand + Linker) Thalidomide-NH-C10-Boc (HY-161961) to produce the PROTAC molecule dCE-2 (HY-161958)^[1].
IC₅₀ & Target	EP300/CBP^[1]
분자량	358.40
화학식	C₂₀H₁₈N₆O
SMILES	NC1=CC(C2=NN(C)C=C2)=CC(C(NC3=CC=CC4=C3C=C(C)N=N4)=O)=C1
선적	Room temperature in continental US; may vary elsewhere.
보관	Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서	Data Sheet (270 KB) Handling Instructions (2659 KB)
References	[1]. Structure-Based Design of CBP/EP300 Degraders: When Cooperativity Overcomes Affinity