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Cat. No.: HY-177148

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G256

G256 is a cytochrome P450 substrate with antiarrhythmic properties. In recombinant monooxygenase systems, G256 undergoes N-hydroxylation of the terminal aminoguanidine nitrogen, as well as ring hydroxylation catalyzed by cytochrome P4502C3. G256 generates N-hydroxyaminoguanidine metabolites via N-hydroxylation in liver microsomal fractions. G256 produces phenol metabolites through ring hydroxylation in both liver microsomal fractions and recombinant cytochrome P450 systems. G256 can be used for research on arrhythmias.

For research use only. We do not sell to patients.

CAS No.: 134867-97-3
Formula: C₁₄H₁₄ClN₅
Molecular Weight:287.75

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (271 KB)

G256 Chemical Structure

CAS No.: 134867-97-3

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
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Biological Activity

Description

All Cytochrome P450 Isoforms :

In Vitro

G256 (compound 1) undergoes P450-dependent N-hydroxylation catalyzed by rabbit liver microsomes to form NOH-G256, with a K_m value of 62.9 μM^[1].
G256 undergoes N-hydroxylation catalyzed by rat liver microsomes to form NOH-G256^[1].
G256 undergoes N-hydroxylation to form NOH-G256 under the catalysis of recombinant systems rich in rabbit liver P450 or purified recombinant P4502C3 systems^[1].
G256 undergoes aromatic hydroxylation catalyzed by rabbit and rat liver microsomes as well as the recombinant rabbit liver P450 monooxygenase system to form phenolic metabolites^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

G256 (compound 1) is a cytochrome P450 substrate. In vivo animal experiments confirm that its antiarrhythmic activity meets the Vaughan-Williams classification criteria and exhibits characteristics of class Ⅰ antiarrhythmic drugs^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 134867-97-3
Molecular Weight 287.75
Formula C₁₄H₁₄ClN₅
SMILES

N=C(N)N/N=C(C1=CC=CC=C1)\C2=C(N)C=CC(Cl)=C2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (271 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Clement B, et al. Cytochrome P450-dependent N-hydroxylation of an aminoguanidine (amidinohydrazone) and microsomal retroreduction of the N-hydroxylated product. Xenobiotica; the fate of foreign compounds in biological systems. 1994 Jul;24(7):671-88. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
- Description
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References

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G256

All Cytochrome P450 Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

G256 Related Classifications

HY-177148 Related Classifications