Antimalarial agent 37
Antimalarial agent 37 (compound 33) is a selective inhibitor against Type Ⅱ kinase with antiplasmodial activity. Antimalarial agent 37 exhibited cytotoxicity and selectivity towards cancer cells HepG2 and MCF 7.
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- No. CAS: 2982633-16-7
- Fòrmula: C32H29F6N5O2S
- Peso molecular:661.66
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Actividad biológica
Descripciòn
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HepG2 | EC50 |
2850 nM
Compound: 33
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Cytotoxicity against human HepG2 cells assessed as reduction in cell viability incubated for 48 hrs by MTS assay
Cytotoxicity against human HepG2 cells assessed as reduction in cell viability incubated for 48 hrs by MTS assay
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[PMID: 38214254] |
| MCF7 | EC50 |
3540 nM
Compound: 33
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Cytotoxicity against human MCF7 cells assessed as reduction in cell viability incubated for 48 hrs by MTS assay
Cytotoxicity against human MCF7 cells assessed as reduction in cell viability incubated for 48 hrs by MTS assay
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[PMID: 38214254] |
In Vitro
Antimalarial agent 37 (0-50 nM, 72 h) exhibits antiplasmodial activities, with EC50 values of 31 nM and 35 nM for strains Dd2 and 3D7, respectively[1].
Antimalarial agent 37 exhibits microsomal stability in mouse liver microsome with half-time of 41.4 min and clearance of 17 μL/min/mg[1].
Antimalarial agent 37 (0-5000 nM, 48 h) reveals cytotoxicity in cells HepG2 and MCF 7, with EC50 values of 2850 and 3540 nM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:P. falciparum Dd2 and P. falciparum 3D7 strains
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Concentration:0-50 nM
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Incubation Time:72 h
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Result:Exhibited antiplasmodial activities with EC50 values of 31 nM and 35 nM for strains Dd2 and 3D7.
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Cell Line:HepG2, MCF7
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Concentration:0-5000 nM
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Incubation Time:48 h
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Result:Revealed cytotoxicity in HepG2 and MCF7, with EC50 values of 2850 nM and 3540 nM as well as selectivity index of 92 and 114, respectively
Chemical Information
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No. CAS 2982633-16-7
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Peso molecular 661.66
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Fòrmula C32H29F6N5O2S
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SMILES
CCN1CCN(CC1)CC2=CC=C(C=C2C(F)(F)F)NC(C3=CC(NC(C4=CC(C5=CC=CS5)=CN=C4)=O)=CC(C(F)(F)F)=C3)=O
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Antimalarial agent 37 Related Classifications
HY-161171 Related Classifications
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