TZD18
TZD18 is a potent and orally active PPARα and PPARγ dual agonist with IC50 values of 0.028, 0.057, >10 µM for PPARα, PPARγ, PPARδ, respectively. TZD18 reduces plasma levels of both glucose and triglycerides in diabetic mice. TZD18 has the potential for the research of type 2 diabetes.
For research use only. We do not sell to patients.
- CAS No.: 228577-00-2
- Formula: C27H27NO5S
- Molecular Weight:477.57
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
- Purity & Documentation
- References
-
Help & FAQs
Biological Activity
|
hPPARα 0.028 μM (IC50) |
hPPARγ 0.057 μM (IC50) |
PPARδ >10 μM (IC50) |
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| COS-1 | EC50 |
>3 μM
Compound: 12
|
In vitro transactivation of human Peroxisome proliferator activated receptor delta measured in PPAR-GAL4 chimeric COS-1 cells
In vitro transactivation of human Peroxisome proliferator activated receptor delta measured in PPAR-GAL4 chimeric COS-1 cells
|
[PMID: 12873517] |
| COS-1 | EC50 |
0.014 μM
Compound: 12
|
In vitro transactivation of human peroxisome proliferator activated receptor gamma measured in PPAR-GAL4 chimeric COS-1 cells
In vitro transactivation of human peroxisome proliferator activated receptor gamma measured in PPAR-GAL4 chimeric COS-1 cells
|
[PMID: 12873517] |
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Animal Model:12-13 weeks, Male db/db and nondiabetic db/+ (lean) mice (type 2 diabetes) [1]
-
Dosage:3, 10 mg/kg
-
Administration:P.o.; daily for 11 days
-
Result:Reduced hyperglycemia and plasma triglyceride levels.
Chemical Information
-
CAS No. 228577-00-2
-
Molecular Weight 477.57
-
Formula C27H27NO5S
-
SMILES
O=C(SC1C2=CC=CC(OCCCOC3=CC=C(C=C3CCC)OC4=CC=CC=C4)=C2)NC1=O
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
TZD18 Related Classifications
HY-121798 Related Classifications
Powered by Bioz