Quarfloxin
Based on 10 publication(s) in Google Scholar
Quarfloxin (CX-3543), a fluoroquinolone derivative with antineoplastic activity, targets and inhibits RNA pol I activity, with IC50 values in the nanomolar range in neuroblastoma cells. Quarfloxin disrupts the interaction between the nucleolin protein and a G-quadruplex DNA structure in the ribosomal DNA (rDNA) template.
Para uso exclusivo en investigación. No vendemos a pacientes.
- Pureza: 99.87%
- No. CAS: 865311-47-3
- Fòrmula: C35H33FN6O3
- Peso molecular:604.67
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Almacenamiento:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
- Pureza y Documentación
- Referencias
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Quarfloxin
More- Cancer Res. 2022 Mar 15;82(6):1013-1024. [Abstract]
- Nucleic Acids Res. 2024 Sep 17:gkae797. [Abstract]
- Int J Biol Macromol. 2023 Aug 1:245:125443. [Abstract]
- Sci Signal. 2024 Oct 22;17(859):eadi8753. [Abstract]
- Eur J Med Chem Rep. 2025 Dec.
- Development. 2024 Nov 1;151(21):dev202875. [Abstract]
- Biochimie. 2022 Apr 20;199:81-91. [Abstract]
- Chembiochem. 2024 Jun 17;25(12):e202400210. [Abstract]
- bioRxiv. 2024 July 27.
- Utrecht University. 2023 Feb.
Ver todos los productos específicos de isoformas DNA/RNA Synthesis
More
Actividad biológica
RNA pol I[1].
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HeLa | IC50 |
4.44 μM
Compound: Quarfloxin
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Cytotoxicity against human HeLa cells
Cytotoxicity against human HeLa cells
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[PMID: 34124673] |
Quarfloxin (CX-3543) effectively inhibits the growth of neuroblastoma cells in vitro. MNA (or high c-Myc) and wt-TP53 cell lines are found to be more sensitive to Quarfloxin. Quarfloxin and induces DNA damage, p53 signaling, cell death, and cell cycle arrest in neuroblastoma cell lines[1].
Solution in vitro: Quarfloxin is suspended in DMSO to a stock of 10 mM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
| NCT Number | Sponsor | Condition | Start Date |
Phase
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|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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No. CAS 865311-47-3
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Appearance Solid
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Peso molecular 604.67
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Fòrmula C35H33FN6O3
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Color Light yellow to yellow
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SMILES
O=C(C1=CN2C3=C(C(N4CC(C5=NC=CN=C5)CC4)=C(F)C=C3C1=O)OC6=CC7=CC=CC=C7C=C26)NCC[C@H]8N(C)CCC8
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Synonyms
CX-3543
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year
Publications (10)
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Journal Impact Factor
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Most Recent
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Cancer Res
Combined Inactivation of CTPS1 and ATR Is Synthetically Lethal to MYC-Overexpressing Cancer Cells. [Abstract]2022 Mar 15;82(6):1013-1024. PMID: 35022212 -
Nucleic Acids Res
G-quadruplexes in an SVA retrotransposon cause aberrant TAF1 gene expression in X-linked dystonia parkinsonism. [Abstract]2024 Sep 17:gkae797. PMID: 39287133 -
Int J Biol Macromol
Unveiling the role of G-quadruplex structure in promoter region: Regulation of ABCA1 expression in macrophages possibly via NONO protein recruitment. [Abstract]2023 Aug 1:245:125443. PMID: 37353131 -
Sci Signal
Reciprocal regulation of mTORC1 signaling and ribosomal biosynthesis determines cell cycle progression in activated T cells. [Abstract]2024 Oct 22;17(859):eadi8753. PMID: 39436996 -
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Development
Ribosome biogenesis is essential for hemogenic endothelial cells to generate hematopoietic stem cells. [Abstract]2024 Nov 1;151(21):dev202875. PMID: 39324287 -
Biochimie
Probing the folding pathways of four-stranded intercalated cytosine-rich motifs at single base-pair resolution. [Abstract]2022 Apr 20;199:81-91. PMID: 35452743 -
Chembiochem
Systematic evaluation of benchmark G4 probes and G4 clinical drugs using three biophysical methods: A guideline to evaluate rapidly G4-binding affinity. [Abstract]2024 Jun 17;25(12):e202400210. PMID: 38619969 -
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Solvente y solubilidad
DMSO : 1 mg/mL (1.65 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
H2O : 1 mg/mL (1.65 mM; ultrasonic and adjust pH to 5 with 0.1 M HCl)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
For the following dissolution methods, please prepare the working solution directly:
It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Pureza y Documentación
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Ficha de datos (285 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Instrucciones de manejo (2659 KB)
Referencias
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO / H2O | 1 mM | 1.6538 mL | 8.2690 mL | 16.5379 mL | 41.3449 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Quarfloxin Related Classifications
HY-14776 Related Classifications
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