AG6033
AG6033 is a potential novel CRBN modulator. AG6033 suppresses various tumor cells by modulating the interactions between CRBN and various antitumor target proteins. AG6033 can cause GSPT1 and IKZF1 degradation. AG6033 induces CRBN-dependent cytotoxic effect.
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- No. CAS: 329706-62-9
- Fòrmula: C30H23N5O4
- Peso molecular:517.53
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Actividad biológica
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CRBN |
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Cell Line
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Type | Value | Description | References |
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| A549 | IC50 |
0.853 μM
Compound: AG6033
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Antitumor activity against human A549 cells assessed as inhibition of cell growth incubated for 48 hrs by MTS assay
Antitumor activity against human A549 cells assessed as inhibition of cell growth incubated for 48 hrs by MTS assay
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[PMID: 35413617] |
AG6033 (0.064-40 μM, 4 h) has potent inhibition ability against A549[1].
AG6033 (1-10 μM, 24 h) significantly promotes apoptosis of A549 cells in a dose-dependent manner[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:A549 cells[1]
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Concentration:0.064 μM, 0.32 μM, 1.6 μM, 8 μM, and 40 μM
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Incubation Time:4 h
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Result:Exhibited potent inhibitory ability against A549, with an IC50 of 0.853 μM.
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Cell Line:A549 cells[1]
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Concentration:1 μM, 5 μM, 10 μM
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Incubation Time:24 h
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Result:Significantly promoted apoptosis of A549 cells in a dose-dependent manner, and the proportion of late apoptotic cells were 5.39%, 22.0%, and 29.1%, respectively.
Chemical Information
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No. CAS 329706-62-9
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Peso molecular 517.53
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Fòrmula C30H23N5O4
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SMILES
O=C(N/N=C1C(N(CC(NC2=CC=CC=C2)=O)C3=C\1C=CC=C3)=O)C4=CC=CC(NC(C5=CC=CC=C5)=O)=C4
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
AG6033 Related Classifications
HY-143435 Related Classifications
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