APG808
Based on 1 Customer Validation
APG808 (PR001) is an anti-human IL-4Rα monoclonal antibody. APG808 binds to IL-4Rα, prevents IL-13Rα1/IL-4Rα heterodimer formation, and disrupts IL-13 and IL-4 mediated signaling. APG808 ablates Fc and complement effector functions. APG808 can be used for the research of chronic obstructive pulmonary disease, asthma, atopic dermatitis.
Para uso exclusivo en investigación. No vendemos a pacientes.
- Pureza: 97.02%
- Peso molecular:142.63 kDa
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Actividad biológica
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Chemical Information
- Pureza y Documentación
- Referencias
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Help & FAQs
Actividad biológica
Human IgG1 kappa
Human
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IL-4Rα/IL4R/CD124 |
APG808 has a high affinity for human FcRn at pH 6.0, reduced affinity for human FcγRI, FcγRIIIa (F158), and FcγRIIIa (V158), and no detectable binding to human FcγRIIa (H131), FcγRIIa (R131), FcγRIIIb, or C1q[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
| Species | Dose | Route | AUC0-inf | CL | Vss | Bioavailability | T1/2 |
|---|---|---|---|---|---|---|---|
| Cynomolgus Monkey[1] | 25.9 mg/kg | s.c. | 9.77 × 106 ng·h/mL | 2.79 | 101.80 mL/kg | 97.51 % | 27.18 |
IL-4Ra/CD124
Unconjugated
The product can be reconstituted/diluted with sterile PBS or saline.
ELISA, FACS, Functional assay
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Immobilized IL-4R alpha/CD124 Protein, Human (HEK293, HY-P70710) can bind APG808. The ED50 for this effect is 59.8 ng/mL.
Chemical Information
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Appearance Liquid
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Peso molecular 142.63 kDa
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Color Colorless to light yellow
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SMILES
[APG808]
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Synonyms
PR001
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Envío
Shipping with dry ice.
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Formulation
Please refer to the lot-specific COA for specific buffer information.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
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Ficha de datos (281 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Inhibitory Antibodies User Guide (603 KB)
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
APG808 Related Classifications
HY-P992034 Related Classifications
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